Medium-chain dicarboxylic acids: chemistry, pharmacological properties, and applications in modern pharmaceutical and cosmetics industries.

Autor:	Liao Z; Food Technology Division, School of Industrial Technology, Universiti Sains Malaysia 11800 USM Penang Malaysia 670058674@qq.com., Yeoh YK; School of Housing, Building and Planning, Universiti Sains Malaysia 11800 USM Penang Malaysia., Parumasivam T; School of Pharmaceutical Sciences, Universiti Sains Malaysia 11800 USM Penang Malaysia thaigarp@usm.my., Koh WY; Faculty of Food Science and Nutrition, Universiti Malaysia Sabah Jalan UMS 88400 Kota Kinabalu Sabah Malaysia., Alrosan M; College of Health Sciences, QU Health, Qatar University P.O. Box 2713 Doha Qatar.; Applied Science Research Center, Applied Science Private University Al-Arab St. 21 Amman 11931 Jordan., Alu'datt MH; Department of Food Science & Nutrition, College of Life Sciences, Kuwait University P.O. Box. 5969 Safat 13060 Kuwait., Tan TC; Food Technology Division, School of Industrial Technology, Universiti Sains Malaysia 11800 USM Penang Malaysia 670058674@qq.com.; Renewable Biomass Transformation Cluster, School of Industrial Technology, Universiti Sains Malaysia 11800 USM Penang Malaysia thuanchew@usm.my +604-653 6375 +604-653 6217.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2024 May 28; Vol. 14 (24), pp. 17008-17021. Date of Electronic Publication: 2024 May 28 (Print Publication: 2024).
DOI:	10.1039/d4ra02598a
Abstrakt:	Succinic (SUA), glutaric (GLA), pimelic (PA), suberic (SUBA), adipic (ADA), azelaic (AZA), and sebacic acids (SA) make up the majority of medium-chain dicarboxylic acids (MCDAs) with chain lengths of C4-C10, and are widely utilised in the chemical, food, textile, pesticide, pharmaceutical, and liquid crystal sectors. The MCDAs' two carboxyl groups provide them with an incredibly broad variety of applications. The focus of significant scientific research now is on the increasingly varied pharmacological effects of MCDAs. However, only a few studies have compared the biological characteristics of MCDAs in the contemporary pharmaceutical and cosmetic sectors and thoroughly examined the most recent research and marketing initiatives for MCDAs. This review's objective is to offer a thorough analysis of academic works on MCDAs, to assess the usefulness of these substances' chemical-pharmacological properties for use in the contemporary pharmaceutical and cosmetic industries, and to investigate the direction of their possible applications in these two disciplines. In addition, this review investigates how these compounds are metabolised in the human body. Competing Interests: There are no conflicts of interest. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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