Background Breast Parenchymal Signal During Menstrual Cycle on Diffusion-Weighted MRI: A Prospective Study in Healthy Premenopausal Women.

Autor: Kim YS; Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Yun B; Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea. yunbola@gmail.com., Chu AJ; Department of Radiology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea., Lee SH; Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Shin HJ; Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Kim SM; Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Jang M; Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Shin SU; Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Moon WK; Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jazyk: angličtina
Zdroj: Korean journal of radiology [Korean J Radiol] 2024 Jun; Vol. 25 (6), pp. 511-517.
DOI: 10.3348/kjr.2023.1189
Abstrakt: Objective: To prospectively investigate the influence of the menstrual cycle on the background parenchymal signal (BPS) and apparent diffusion coefficient (ADC) of the breast on diffusion-weighted MRI (DW-MRI) in healthy premenopausal women.
Materials and Methods: Seven healthy premenopausal women (median age, 37 years; range, 33-49 years) with regular menstrual cycles participated in this study. DW-MRI was performed during each of the four phases of the menstrual cycle (four examinations in total). Three radiologists independently assessed the BPS visual grade on images with b-values of 800 sec/mm² (b800), 1200 sec/mm² (b1200), and a synthetic 1500 sec/mm² (sb1500). Additionally, one radiologist conducted a quantitative analysis to measure the BPS volume (%) and ADC values of the BPS (ADC BPS ) and fibroglandular tissue (ADC FGT ). Changes in the visual grade, BPS volume (%), ADC BPS , and ADC FGT during the menstrual cycle were descriptively analyzed.
Results: The visual grade of BPS in seven women varied from mild to marked on b800 and from minimal to moderate on b1200 and sb1500. As the b-value increased, the visual grade of BPS decreased. On b800 and sb1500, two of the seven volunteers showed the highest visual grade in the early follicular phase (EFP). On b1200, three of the seven volunteers showed the highest visual grades in EFP. The BPS volume (%) on b800 and b1200 showed the highest value in three of the six volunteers with dense breasts in EFP. Three of the seven volunteers showed the lowest ADC BPS in the EFP. Four of the seven volunteers showed the highest ADC BPS in the early luteal phase (ELP) and the lowest ADC FGT in the late follicular phase (LFP).
Conclusion: Most volunteers did not exhibit specific BPS patterns during their menstrual cycles. However, the highest BPS and lowest ADC BPS were more frequently observed in EFP than in the other menstrual cycle phases, whereas the highest ADC BPS was more common in ELP. The lowest ADC FGT was more frequent in LFP.
Competing Interests: The authors have no potential conflicts of interest to disclose.
(Copyright © 2024 The Korean Society of Radiology.)
Databáze: MEDLINE
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