Effect of short-term exposure to the strobilurin fungicide dimoxystrobin: Morphofunctional, behavioural and mitochondrial alterations in Danio rerio embryos and larvae.

Autor: Ahmed AIM; Department of Biology, Ecology and Earth Science (DiBEST) - University of Calabria, Via P. Bucci 4/B, Rende, Cosenza 87036, Italy., Macirella R; Department of Biology, Ecology and Earth Science (DiBEST) - University of Calabria, Via P. Bucci 4/B, Rende, Cosenza 87036, Italy., Talarico F; Department of Biology, Ecology and Earth Science (DiBEST) - University of Calabria, Via P. Bucci 4/B, Rende, Cosenza 87036, Italy., Muoio MF; Department of Biology, Ecology and Earth Science (DiBEST) - University of Calabria, Via P. Bucci 4/B, Rende, Cosenza 87036, Italy., Mezzasalma M; Department of Biology, Ecology and Earth Science (DiBEST) - University of Calabria, Via P. Bucci 4/B, Rende, Cosenza 87036, Italy., Tronci V; Fish Biology and Aquaculture Group, Ocean and Environment Department, NORCE Norwegian Research Center, Bergen 5006, Norway., Lal P; Fish Biology and Aquaculture Group, Ocean and Environment Department, NORCE Norwegian Research Center, Bergen 5006, Norway., Gharbi N; Fish Biology and Aquaculture Group, Ocean and Environment Department, NORCE Norwegian Research Center, Bergen 5006, Norway. Electronic address: nagh@norceresearch.no., Brunelli E; Department of Biology, Ecology and Earth Science (DiBEST) - University of Calabria, Via P. Bucci 4/B, Rende, Cosenza 87036, Italy. Electronic address: elvira.brunelli@unical.it.
Jazyk: angličtina
Zdroj: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2024 Jul 01; Vol. 279, pp. 116493. Date of Electronic Publication: 2024 May 27.
DOI: 10.1016/j.ecoenv.2024.116493
Abstrakt: Strobilurins, among the most used fungicides worldwide, are considered non-toxic to mammals and birds, but there is growing evidence that these compounds are highly toxic to aquatic species. Dimoxystrobin has been included in the 3rd Watch List of the European Commission, and it has been classified as very toxic to aquatic life. However, previous studies focused on acute toxicity and only two reports are available on its impact on fish, and none on its effects during the early life stages. Here, we evaluated for the first time the effects induced on zebrafish embryos and larvae by two dimoxystrobin sublethal concentrations (6.56 and 13.13 μg/L) falling in the range of predicted environmental concentrations. We demonstrated that short-term exposure to dimoxystrobin may exert adverse effects on multiple targets, inducing severe morphological alterations. Moreover, we showed enhanced mRNA levels of genes related to the mitochondrial respiratory chain and ATP production. Impairment of the swim bladder inflation has also been recorded, which may be related to the observed swimming performance alterations.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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