Responsiveness of the condition-specific OVAMA questionnaire to measure symptoms and appearance in patients with vascular malformations.

Autor:	Stor MLE; Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Public Health, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, The Netherlands., Lokhorst MM; Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Public Health, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, The Netherlands., Horbach SER; Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Public Health, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, The Netherlands., Luijten MAJ; Child and Adolescent Psychiatry & Psychosocial Care, Amsterdam Reproduction and Development, Amsterdam Public Health, Amsterdam University Medical Centres, University of Amsterdam, Emma Children's Hospital, Amsterdam, The Netherlands.; Amsterdam Public Health, Mental Health and Methodology, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development, Child Development, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, The Netherlands., Spuls PI; Department of Dermatology, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Amsterdam, The Netherlands., van der Horst CMAM; Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Public Health, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	The British journal of dermatology [Br J Dermatol] 2024 May 28. Date of Electronic Publication: 2024 May 28.
DOI:	10.1093/bjd/ljae213
Abstrakt:	Background: Evidence-based guidelines for the treatment of vascular malformations are not readily available, possibly due to the diversity in methods used to evaluate treatment efficacy in clinical research, complicating the aggregation and comparison of study results. The OVAMA (Outcome Measures for VAscular Malformations) questionnaire was developed to uniformly measure symptoms and appearance, i.e., condition-specific core outcome domains, in patients with vascular malformations. However, the OVAMA questionnaire needs to be responsive to changes in these constructs in order to assess whether the disease status has altered since treatment. Objectives: To assess the responsiveness of the OVAMA questionnaire in patients with vascular malformations. Methods: In a prospective longitudinal study, patients completed the OVAMA questionnaire at baseline and eight weeks follow-up since treatment or watchful waiting policy. Additionally, patients completed the Global rating of change (GRC) scales at follow-up. Responsiveness was evaluated following the criterion approach of testing predefined hypotheses about expected relationships between the OVAMA questionnaire and GRC scales, measuring the same constructs. The OVAMA questionnaire was considered responsive if ≥ 75% of the hypotheses were confirmed. Results: Between July 2020 and September 2022, 89 patients were recruited in a vascular anomaly centre in the Netherlands, of which 63 patients completed the questionnaires at baseline and follow-up. In total, fifteen constructs of the OVAMA questionnaire were assessed for five hypotheses. Of these 75 hypotheses, 63 (84%) hypotheses were confirmed and thereby providing evidence that the OVAMA questionnaire is responsive to change. Conclusion: Our study found convincing evidence that the OVAMA questionnaire is responsive to changes in symptoms and appearance in patients with vascular malformations. In addition to determining a baseline of symptoms and appearance, the OVAMA questionnaire can now be used to evaluate the effect of treatment from the patient's perspective. The responsive OVAMA questionnaire allows for uniform evaluation and comparison of the effects of treatment on the condition-specific core outcome domains, tackling heterogeneity in outcome measurement and improving the clinical research of vascular malformations. (© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists.)
Databáze:	MEDLINE
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