Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study.

Autor: Sousa-Pinto B; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.; Faculty of Medicine, CINTESIS@RISE - Health Research Network, University of Porto, Porto, Portugal., Louis G; Department of Public Health, University of Liège, Liège, Belgium.; GIGA I3 Research Group, University of Liège, Liège, Belgium., Vieira RJ; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.; Faculty of Medicine, CINTESIS@RISE - Health Research Network, University of Porto, Porto, Portugal., Czarlewski W; Medical Consulting Czarlewski, Levallois, France.; MASK-air, Montpellier, France., Anto JM; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., Amaral R; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.; Faculty of Medicine, CINTESIS@RISE - Health Research Network, University of Porto, Porto, Portugal., Sá-Sousa A; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.; Faculty of Medicine, CINTESIS@RISE - Health Research Network, University of Porto, Porto, Portugal., Brussino L; Department of Medical Sciences, University of Torino, Torino, Italy.; Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy., Canonica GW; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Asthma and Allergy Unit, IRCCS Humanitas Research Hospital, Milan, Italy., Loureiro CC; Department of Pneumology, Faculty of Medicine, Coimbra University Hospital, Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research, CIBB, Coimbra, Portugal., Cruz AA; Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil., Gemicioglu B; Department of Pulmonary Diseases, Faculty of Medicine, Istanbul University-Cerrahpaşa, Cerrahpaşa, Istanbul, Turkey.; Institute of Pulmonology and Tuberculosis, Istanbul University-Cerrahpaşa, Istanbul, Turkey., Haahtela T; Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Kupczyk M; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland., Kvedariene V; Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Department of Pathology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania., Larenas-Linnemann DE; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico., Pham-Thi N; Ecole Polytechnique de Palaiseau, Palaiseau, France.; IRBA (Institut de Recherche Bio-Médicale des Armées), Brétigny sur Orge, France.; Université Paris Cité, Paris, France., Puggioni F; IRCCS Humanitas Research Center, Personalized Medicine Asthma & Allergy, Rozzano, Milan, Italy., Regateiro FS; Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.; Faculty of Medicine, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, Portugal.; UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal., Romantowski J; Department of Allergology, Medical University of Gdańsk, Gdansk, Poland., Sastre J; Allergy Service, Fundacion Jimenez Diaz, Autonoma University of Madrid, CIBERES-ISCIII, Madrid, Spain., Scichilone N; PROMISE Department, University of Palermo, Palermo, Italy., Taborda-Barata L; UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal., Ventura MT; Allergy and Clinical Immunology, University of Bari Medical School, Bari, Italy.; Institute of Sciences of Food Production, National Research Council (ISPA-CNR), Bari, Italy., Agache I; Faculty of Medicine, Transylvania University Brasov, Brasov, Romania., Bedbrook A; MASK-air, Montpellier, France.; ARIA, Montpellier, France., Benfante A; PROMISE Department, University of Palermo, Palermo, Italy., Bergmann KC; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany., Bosnic-Anticevich S; Quality Use of Respiratory Medicines Group, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.; Macquarie Medical School, Macquarie University, Macquarie Park, New South Wales, Australia., Bonini M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.; National Heart and Lung Institute (NHLI), Imperial College London, London, UK., Boulet LP; Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada., Brusselle G; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Buhl R; Department of Pulmonary Medicine, Mainz University Hospital, Mainz, Germany., Cecchi L; SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy., Charpin D; Clinique des Bronches, Allergie et Sommeil, Hôpital Nord, Marseille, France., Costa EM; CINTESIS@RISE, Biochemistry Lab, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing, University of Porto, Porto, Portugal., Del Giacco S; Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital 'Duilio Casula', University of Cagliari, Cagliari, Italy., Jutel M; Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland.; ALL-MED Medical Research Institute, Wroclaw, Poland., Klimek L; Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.; Center for Rhinology and Allergology, Wiesbaden, Germany., Kuna P; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland., Laune D; KYomed INNOV, Montpellier, France., Makela M; Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Morais-Almeida M; Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal., Nadif R; Université Paris-Saclay, UVSQ, University Paris-Sud, Villejuif, France.; Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France., Niedoszytko M; UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.; Department of Allergology, Medical University of Gdańsk, Gdansk, Poland., Papadopoulos NG; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece., Papi A; Respiratory Medicine, Department of Translational Medicine, University of Ferrara, Ferrara, Italy., Pfaar O; Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany., Rivero-Yeverino D; Servicio de Alergia e Inmunología clínica, Hospital Universitario de Puebla, Puebla, México., Roche N; Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France.; Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, Paris, France.; UMR 1016, Institut Cochin, Paris, France., Samolinski B; Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland., Shamji MH; National Heart and Lung Institute (NHLI), Imperial College London, London, UK.; NIHR Imperial Biomedical Research Centre, London, UK., Sheikh A; Usher Institute, The University of Edinburgh, Edinburgh, UK., Ulrik CS; Department of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Usmani OS; National Heart and Lung Institute (NHLI), Imperial College London, London, UK.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Airways Disease Section, Royal Brompton Hospital, London, UK., Valiulis A; Interdisciplinary Research Group of Human Ecology, Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.; European Academy of Paediatrics (EAP/UEMS-SP), Brussel, Belgium., Yorgancioglu A; Department of Pulmonary Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey., Zuberbier T; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany., Fonseca JA; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.; Faculty of Medicine, CINTESIS@RISE - Health Research Network, University of Porto, Porto, Portugal., Pétré B; Department of Public Health, University of Liège, Liège, Belgium., Louis R; GIGA I3 Research Group, University of Liège, Liège, Belgium.; Department of Pulmonary Medicine, CHU Liège, Liège, Belgium., Bousquet J; MASK-air, Montpellier, France.; ARIA, Montpellier, France.; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.; Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France.
Jazyk: angličtina
Zdroj: Clinical and translational allergy [Clin Transl Allergy] 2024 Jun; Vol. 14 (6), pp. e12358.
DOI: 10.1002/clt2.12358
Abstrakt: Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control.
Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control.
Methods: In this cross-sectional study, we assessed real-world data using the MASK-air ® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma.
Measurement and Main Results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma.
Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
(© 2024 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.)
Databáze: MEDLINE
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