| Autor: |
Saitani EM; Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Zografou, Greece. elminasait@pharm.uoa.gr., Pippa N; Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Zografou, Greece. elminasait@pharm.uoa.gr., Perinelli DR; School of Pharmacy, Chemistry Interdisciplinary Project (CHIP), University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy. diego.perinelli@unicam.it., Forys A; Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34, M. Curie-Skłodowskiej St, 41-819 Zabrze, Poland. aforys@cmpw-pan.pl., Papakyriakopoulou P; Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Zografou, Greece. elminasait@pharm.uoa.gr., Lagopati N; Department of Basic Medical Science, Laboratory of Biology, School of Medicine National and Kapodistrian University of Athens, 11527 Athens, Greece. nlagopati@med.uoa.gr.; Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece., Bonacucina G; School of Pharmacy, Chemistry Interdisciplinary Project (CHIP), University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy. diego.perinelli@unicam.it., Trzebicka B; Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34, M. Curie-Skłodowskiej St, 41-819 Zabrze, Poland. aforys@cmpw-pan.pl., Gazouli M; Department of Basic Medical Science, Laboratory of Biology, School of Medicine National and Kapodistrian University of Athens, 11527 Athens, Greece. nlagopati@med.uoa.gr., Pispas S; Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece. pispas@eie.gr., Valsami G; Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Zografou, Greece. elminasait@pharm.uoa.gr. |
| Abstrakt: |
In this study, we designed and developed systems composed of poly(ethylene-oxide)- b -poly(ε-caprolactone) block copolymers of different molecular weights and compositions, non-ionic surfactant, and cyclodextrins. The innovation of this study lies in the combination of these diverse biomaterials to create biomimetic and bioinspired drug delivery supramolecular structures. The systems were formed by the thin-film hydration method. Extensive physicochemical and morphological characterization was conducted using differential scanning calorimetry, light scattering techniques, microcalorimetry analysis, high-resolution ultrasound spectroscopy, surface tension measurements, fluorescence spectroscopy, cryogenic transmission electron microscopy images, and in vitro cytotoxicity evaluation. These innovative hybrid nanoparticles were found to be attractive candidates as drug delivery systems with unique properties by encompassing the physicochemical and thermotropic properties of both classes of materials. Subsequently, Ropinirole hydrochloride was used as a model drug for the purpose of this study. These systems showed a high RH content (%), and in vitro diffusion experiments revealed that more than 90% of the loading dose was released under pH and temperature conditions that simulate the conditions of the nasal cavity. Promising drug release performance was observed with all tested formulations, worth further investigation to explore both ex vivo permeation through the nasal mucosa and in vivo performance in an experimental animal model. |
