Pre-Infection Nutritional Status, Oxidative Stress, and One-Year-Long COVID Persistence in Patients Undergoing Hemodialysis: A Prospective Cohort Study.

Autor: Stepanova N; State Institution 'O.O. Shalimov National Scientific Center of Surgery and Transplantology of the National Academy of Medical Science of Ukraine', 03680 Kyiv, Ukraine.; Dialysis Medical Center LLC 'Nephrocenter', 03057 Kyiv, Ukraine., Korol L; State Institution 'O.O. Shalimov National Scientific Center of Surgery and Transplantology of the National Academy of Medical Science of Ukraine', 03680 Kyiv, Ukraine., Ostapenko T; Dialysis Medical Center LLC 'Nephrocenter', 69035 Zaporizhzhia, Ukraine., Marchenko V; Dialysis Medical Center LLC 'Nephrocenter', 69035 Zaporizhzhia, Ukraine., Belousova O; Dialysis Medical Center LLC 'Nephrocenter', 69035 Zaporizhzhia, Ukraine., Snisar L; Dialysis Medical Center LLC 'Nephrocenter', 03057 Kyiv, Ukraine., Shifris I; State Institution 'O.O. Shalimov National Scientific Center of Surgery and Transplantology of the National Academy of Medical Science of Ukraine', 03680 Kyiv, Ukraine., Kolesnyk M; State Institution 'O.O. Shalimov National Scientific Center of Surgery and Transplantology of the National Academy of Medical Science of Ukraine', 03680 Kyiv, Ukraine.
Jazyk: angličtina
Zdroj: Clinics and practice [Clin Pract] 2024 May 17; Vol. 14 (3), pp. 892-905. Date of Electronic Publication: 2024 May 17.
DOI: 10.3390/clinpract14030070
Abstrakt: Background: Nutritional status's role in long COVID is evident in the general population, yet unexplored in patients undergoing hemodialysis (HD), posing a research gap. We hypothesized that pre-infection undernutrition in HD patients might impact long COVID persistence by accelerating oxidative stress. The present study aimed to investigate the association between pre-infection nutritional status, oxidative stress, and one-year-long COVID persistence in HD patients.
Methods: This prospective observational cohort study enrolled 115 HD patients with confirmed COVID-19. Nutritional status was assessed using the Controlling Nutritional Status (CONUT) score twice: before infection and three months post-infection. Oxidative markers included malondialdehyde (MDAs), ceruloplasmin, transferrin, and sulfhydryl groups. The endpoint was one-year-long COVID persistence.
Results: Moderate pre-infection CONUT scores were associated with heightened severe undernutrition risk ( p < 0.0001), elevated MDAs ( p < 0.0001), and reduced ceruloplasmin levels ( p = 0.0009) at three months post-COVID-19 compared to light CONUT scores. Pre-infection CONUT score independently predicted post-COVID oxidative damage [OR 2.3 (95% CI 1.2; 4.6), p < 0.0001] and one-year-long COVID persistence [HR 4.6 (95% CI 1.4; 9.9), p < 0.0001], even after adjusting for potential confounders.
Conclusion: Moderate pre-infection undernutrition heightens post-COVID oxidative stress and increases the risk of one-year-long COVID persistence in HD patients.
Databáze: MEDLINE
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