Thrombosis of the vasa vasorum of the large and medium size pulmonary artery and vein leads to pulmonary thromboembolism in COVID-19.
| Autor: | Daisley H; General Hospital, San Fernando, Trinidad and Tobago., Acco O; The University of the West Indies, Mona, Jamaica., Daisley M; Princess Alexandra Hospital, The Valley, Anguilla., George D; Scarborough General Hospital, Signal Hill, Trinidad and Tobago., Paul L; The University of the West Indies, Mona, Jamaica., James E; Beacon Plastic and Cosmetic Surgery, Woodbrook, Port of Spain, Trinidad and Tobago., Rampersad A; General Hospital, San Fernando, Trinidad and Tobago., Narinesingh F; General Hospital, San Fernando, Trinidad and Tobago., Humphrey O; General Hospital, San Fernando, Trinidad and Tobago., Daisley J; Scarborough General Hospital, Signal Hill, Trinidad and Tobago., Nathan M; The University of the West Indies, St Augustine, Trinidad and Tobago. |
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| Jazyk: | angličtina |
| Zdroj: | Autopsy & case reports [Autops Case Rep] 2024 May 22; Vol. 14, pp. e2024491. Date of Electronic Publication: 2024 May 22 (Print Publication: 2024). |
| DOI: | 10.4322/acr.2024.491 |
| Abstrakt: | The vasa vasorum of the large pulmonary vessels is involved in the pathology of COVID-19. This specialized microvasculature plays a major role in the biology and pathology of the pulmonary vessel walls. We have evidence that thrombosis of the vasa vasorum of the large and medium-sized pulmonary vessels during severe COVID-19 causes ischemia and subsequent death of the pulmonary vasculature endothelium. Subsequent release of thrombi from the vasa interna into the pulmonary circulation and pulmonary embolism generated at the ischemic pulmonary vascular endothelium site, are the central pathophysiological mechanisms in COVID-19 responsible for pulmonary thromboembolism. The thrombosis of the vasa vasorum of the large and medium-sized pulmonary vessels is an internal event leading to pulmonary thromboembolism in COVID-19. Competing Interests: Conflict of interest: None. (Copyright © 2024 The Author(s).) |
| Databáze: | MEDLINE |
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