Biomonitoring Study of Urinary Bisphenol A Levels and Impact of Bottle-Feeding Practices Among Infants and Children From Northern India.

Autor: Gangadaran P; Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Bharti B; Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Correspondence to: Dr. Bhavneet Bharti, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India. bhavneetsahul@gmail.com., Attri SV; Department of Pediatric Biochemistry, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Malik VS; Department of Community Medicine, School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Patial A; Department of Pediatric Biochemistry, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Jazyk: angličtina
Zdroj: Indian pediatrics [Indian Pediatr] 2024 Jul 15; Vol. 61 (7), pp. 649-655. Date of Electronic Publication: 2024 May 25.
Abstrakt: Objectives: To compare the urinary bisphenol A (BPA) levels in bottle-fed and never bottle-fed infants and under-five children and to determine the impact of bottle-feeding practices and sociodemographic factors on urinary BPA levels.
Methods: A community-based cross-sectional study was carried out on children aged between 2 to 60 months attending the Anganwadi centres in Chandigarh.
Results: Urine samples were collected from 184 children, out of which 94.56% (n = 174) children had detectable urinary BPA levels. The mean (SD) BPA level was 2.74 (2.60) ng/ml and BPA was detected in 93.9% of 'ever' bottle-fed children (n = 93/99) and 95.3% of 'never' bottle-fed children (n = 81/85) (P = 0.69). On multivariate regression analysis, there were no significant predictors for high (≥ 75th percentile) urinary BPA levels. Still, the odds of urinary BPA levels ≥75th percentile showed higher trend for significance among children from middle/higher socioeconomic background in reference to lower socioeconomic stratum (adjusted OR 7.02; 95% CI 1.24, 133.25; P = 0.07) and among children whose feeding bottles were brushed once or twice daily in reference to group with no daily brushing (adjusted OR 3.92, 95% CI 0.95, 20.56; P = 0.07).
Conclusions: Although feeding with plastic bottle did not emerge as a statistically significant risk factor for BPA exposure, yet detection of BPA levels among majority of study children signals urgent need for unmasking exposure to other sources given the potential long-term toxicity of BPA among infants and young children.
Databáze: MEDLINE
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