| Autor: |
Sciorio R; Fertility Medicine and Gynaecological Endocrinology Unit, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland., Tramontano L; Department of Women, Infants and Adolescents, Division of Obstetrics, Geneva University Hospitals, Boulevard de la Cluse 30, 1211 Genève 14, Switzerland., Greco PF; Villa Mafalda, Centre for Reproductive Medicine, Rome, Italy., Greco E; Villa Mafalda, Centre for Reproductive Medicine, Rome, Italy.; Department of Obstetrics and Gynecology, UniCamillus, International Medical University, Rome, Italy. |
| Jazyk: |
angličtina |
| Zdroj: |
JBRA assisted reproduction [JBRA Assist Reprod] 2024 Aug 26; Vol. 28 (3), pp. 511-520. Date of Electronic Publication: 2024 Aug 26. |
| DOI: |
10.5935/1518-0557.20240034 |
| Abstrakt: |
Following the advancement of medically assisted reproduction (MAR) technology, and the rationale to extend the culture to the blastocyst stage, performing elective single embryo transfer (eSET), gamete quality and assessment have acquired large relevance in ART. Embryo quality is strictly correlated with gametes quality and culture conditions. Oocyte maturity assessment is therefore imperative for fertilization and embryo evolution. Mature oocytes at the metaphase II stage result in a higher fertilization rate compared to immature oocytes. Indeed, oocyte morphology evaluation represents an important and challenging task that may serve as a valuable prognostic tool for future embryo development and implantation potential. Different grading systems have been reported to assess human embryos, however, in many cases, it is still a major challenge to select the single embryo to transfer with the highest implantation potential. Further, eSET has conferred a challenge to embryologists, who must try to enhance embryo culture and selection to provide an adequate success rate, whilst reducing the overall number of embryos transferred. Above the standard morphological assessment, there are several invasive or non-invasive approaches for embryo selection such as preimplantation genetic testing, time-lapse technology, proteomics and metabolomics, as well as oxygen utilization and analysis of oxidative stress in culture medium. This short review is not designed to be a comprehensive review of all possible features that may influence oocyte quality. It does give, however, a brief overview and describes the prognostic value of the morphological characteristics of human oocytes on their developmental capacity following ART treatments. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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