Effects of Outdoor-Grown Royal Sun Medicinal Mushroom Agaricus brasiliensis KA21 (Agaricomycetes) Fruiting Body on Canine Malassezia Dermatitis.

Autor:	Motoi A; Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan; Toei Shinyaku Co. Ltd., Mitaka, Tokyo 181-0011, Japan., Tajima K; Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan., Motoi M; Toei Pharmaceutical Co. Ltd., 2-5-3 Iguchi, Mitaka, Tokyo 181-0011; Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan., Nishihara K; Morino Dogs and Cats Hospital, Kawahira Pet Care Center, Aoba, Sendai, Miyagi 981-0954, Japan., Yamanaka D; Laboratory for Immunopharmacology of Microbial Products School of Pharmacy Tokyo University of Pharmacy and Life Sciences 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan., Ishibashi KI; Laboratory of Host Defense and Responses, Faculty of Nutrition, Kagawa Nutrition University, Sakado, Saitama 350-0288, Japan., Ohno N; Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan., Adachi Y; Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Jazyk:	angličtina
Zdroj:	International journal of medicinal mushrooms [Int J Med Mushrooms] 2024; Vol. 26 (6), pp. 13-23.
DOI:	10.1615/IntJMedMushrooms.2024053187
Abstrakt:	Brazil-grown outdoor-cultivated Agaricus brasiliensis KA21 fruiting body (KA21) significantly increases the production of serum anti-beta-glucan antibody. Therefore, KA21 ingestion may be useful for the prevention and alleviation of fungal infections. This study aimed to determine the effects of KA21 in fungal infections in animals. KA21 was administered to nine dogs infected with Malassezia. Notably, the anti-beta-glucan antibody titer remained unchanged or tended to decrease in the oral steroid arm, whereas in the non-steroid arm, antibody titer increased in almost all animals after KA21 ingestion. Dogs showing improved clinical symptoms exhibited increased anti-beta-glucan antibody titers. The results of this study suggest that KA21 ingestion may alleviate the symptoms of Malassezia and other fungal infections and that continuous ingestion may help prolong recurrence-free intervals. Additionally, the ingestion of KA21 during oral steroid dosage reduction or discontinuation may enable smoother steroid withdrawal.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu