Integrated multi-omics approach reveals novel associations in the rapeseed diet-microbiota-host axis in pigs.

Autor:	Onarman Umu ÖC; Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ås N-1432, Norway., Mydland LT; Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, Ås N-1432, Norway., Chen C; Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108, United States., de Nanclares MP; Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, Ås N-1432, Norway., Shurson GC; Department of Animal Science, University of Minnesota, St Paul, MN 55108, United States., Urriola PE; Department of Animal Science, University of Minnesota, St Paul, MN 55108, United States., Sørum H; Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ås N-1432, Norway., Øverland M; Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, Ås N-1432, Norway.
Jazyk:	angličtina
Zdroj:	ISME communications [ISME Commun] 2024 Apr 23; Vol. 4 (1), pp. ycae061. Date of Electronic Publication: 2024 Apr 23 (Print Publication: 2024).
DOI:	10.1093/ismeco/ycae061
Abstrakt:	Diet-mediated host-microbiota interplay is a key factor in optimizing the gut function and overall health of the host. Gaining insight into the biological mechanisms behind this relationship is fundamental to finding sustainable, environment-friendly feed solutions in livestock production systems. Here, we apply a multi-omics integration approach to elucidate sustainable diet-associated host-gut microbiota interactions in pigs and we demonstrate novel and biologically relevant host-microbe associations in the gut, driven by a rapeseed meal-based feed (RSF). Interestingly, RSF-diet promoted the abundance of segmented filamentous bacteria Candidatus Arthromitus that was associated with the maintenance of mucosal immunity in the ileum of pigs. In the colon, RSF diet affected host mRNA splicing functions, which may result in different host gene products, through host-microbiota associations, particularly with the Faecalibacterium population, and through the interaction of dietary components such as sinapic acid with the host cells. Moreover, telomere maintenance and organization functions that may determine the overall health of the host were upregulated and notably associated with Subdoligranulum population in the colon of RSF diet-fed pigs . This integrative multi-omics approach provides more insight into the diet-microbiota-host axis, and a better understanding of mechanisms and opportunities to find new strategies for modulating host health and potentially improving caloric and nutritional efficiency in animal production. Competing Interests: The authors declare no competing interests. (© The Author(s) 2024. Published by Oxford University Press on behalf of the International Society for Microbial Ecology.)
Databáze:	MEDLINE
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