Tuning Biocompatibility and Bactericidal Efficacy as a Function of Doping of Gold in ZnO Nanocrystals.

Autor:	Oliveira JM; Strategic Materials Laboratory, Physics Institute, Federal University of Alagoas, Maceió, CEP: 57072-900 Alagoas, Brazil.; Laboratory of in vivo Toxicity Analysis, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57072-970, Alagoas, Brazil., Silva DPD; Strategic Materials Laboratory, Physics Institute, Federal University of Alagoas, Maceió, CEP: 57072-900 Alagoas, Brazil.; Rede Nordeste de Biotecnologia (RENORBIO), Chemistry Institute, Federal University of Alagoas, Maceió 57072-900, Alagoas, Brazil.; Laboratory of Wound Treatment Research, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió 57072-970, Alagoas, Brazil., Floresta LRS; Strategic Materials Laboratory, Physics Institute, Federal University of Alagoas, Maceió, CEP: 57072-900 Alagoas, Brazil.; Laboratory of in vivo Toxicity Analysis, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57072-970, Alagoas, Brazil., Rocha GG; Strategic Materials Laboratory, Physics Institute, Federal University of Alagoas, Maceió, CEP: 57072-900 Alagoas, Brazil.; Department of Medicine, Biotechnology Institute, Federal University of Catalão, Catalão 75705-220, Goiás, Brazil., Almeida LIM; Strategic Materials Laboratory, Physics Institute, Federal University of Alagoas, Maceió, CEP: 57072-900 Alagoas, Brazil.; Laboratory of in vivo Toxicity Analysis, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57072-970, Alagoas, Brazil., Dias EHV; Department of Medicine, Biotechnology Institute, Federal University of Catalão, Catalão 75705-220, Goiás, Brazil., Lima TK; Institute of Chemistry, Federal University of Uberlândia, Uberlândia 38400-902, Minas Gerais, Brazil., Marinho JZ; Institute of Chemistry, Federal University of Uberlândia, Uberlândia 38400-902, Minas Gerais, Brazil., Lima MM; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 05508-900, São Paulo, Brazil., Valer FB; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 05508-900, São Paulo, Brazil., Oliveira F; Laboratory of Molecular and Cellular Biology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia 38408-100, Minas Gerais, Brazil., Rocha TL; Laboratory of Environmental Biotechnology and Ecotoxicology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia 74605-050, Goiás, Brazil., Alvino V; Laboratory of Wound Treatment Research, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió 57072-970, Alagoas, Brazil., Anhezini L; Laboratory of in vivo Toxicity Analysis, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57072-970, Alagoas, Brazil., Silva ACA; Strategic Materials Laboratory, Physics Institute, Federal University of Alagoas, Maceió, CEP: 57072-900 Alagoas, Brazil.; Rede Nordeste de Biotecnologia (RENORBIO), Chemistry Institute, Federal University of Alagoas, Maceió 57072-900, Alagoas, Brazil.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2024 May 10; Vol. 9 (20), pp. 21904-21916. Date of Electronic Publication: 2024 May 10 (Print Publication: 2024).
DOI:	10.1021/acsomega.3c09680
Abstrakt:	Doping nanoparticles represents a strategy for modulating the energy levels and surface states of nanocrystals (NCs), thereby enhancing their efficiency and mitigating toxicity. Thus, we herein focus on the successful synthesis of pure and gold (Au)-doped zinc oxide (ZnO) nanocrystals (NCs), investigating their physical-chemical properties and evaluating their applicability and toxicity through in vitro and in vivo assessments. The optical, structural, and photocatalytic characteristics of these NCs were scrutinized by using optical absorption (OA), X-ray diffraction (XRD), and methylene blue degradation, respectively. The formation and doping of the NCs were corroborated by the XRD and OA results. While the introduction of Au as a dopant did induce changes in the phase and size of ZnO, a high concentration of Au ions in ZnO led to a reduction in their photocatalytic activity. This demonstrated a restricted antibacterial efficacy against Escherichia coli , Pseudomonas aeruginosa , and Staphylococcus aureus . Remarkably, Au-doped counterparts exhibited enhanced biocompatibility in comparison to ZnO, as evidenced in both in vitro (murine macrophage cells) and in vivo ( Drosophila melanogaster ) studies. Furthermore, confocal microscopy images showed a high luminescence of Au-doped ZnO NCs in vivo . Thus, this study underscores the potential of Au doping of ZnO NCs as a promising technique to enhance material properties and increase biocompatibility. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu