Chagas disease in the United States: a call for increased investment and collaborative research.
| Autor: | Agudelo Higuita NI; Department of Medicine, Section of Infectious Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Instituto de Enfermedades Infecciosas y Parasitología Antonio Vidal, Tegucigalpa, Honduras., Beatty NL; Department of Medicine, Division of Infectious Diseases and Global Medicine, University of Florida College of Medicine, Gainesville, FL, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Forsyth C; Drugs for Neglected Diseases Initiative-North America, New York, NY, USA., Henao-Martínez AF; Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Manne-Goehler J; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Lancet regional health. Americas [Lancet Reg Health Am] 2024 May 17; Vol. 34, pp. 100768. Date of Electronic Publication: 2024 May 17 (Print Publication: 2024). |
| DOI: | 10.1016/j.lana.2024.100768 |
| Abstrakt: | Chagas disease, caused by the protozoan Trypanosoma cruzi , is a highly overlooked parasitic infection within the United States. It affects an estimated 300,000 individuals, often remaining asymptomatic for years before triggering severe complications such as cardiomyopathy in 30-40% of cases. While many contract the disease in Latin America, its transmission by local vectors in the southern U.S. presents a significant challenge. Unfortunately, limited access to diagnosis and treatment persists, alongside unresolved gaps in healthcare systems and disease pathogenesis. In this viewpoint, we discuss the need for focused research and public health initiatives, with U.S. research institutions playing a crucial role in developing new treatments and identifying biomarkers. Furthermore, investigating the genetic variations of T. cruzi between North and South America is vital for improving diagnostic and treatment strategies. Urgent action is required to implement national and local programs, bolstering healthcare responses and advancing research efforts.Q4As per journal style section heading 'Introduction' is mandatory, hence we have introduced the heading. Please check, and correct if necessary.ResolvedQ5If there are any drug dosages in your article, please verify them and indicate that you have done so by initialing this query.ResolvedQ6Please supply the year of publication.ResolvedFootnoteView Edit Log9. Competing Interests: The authors report no conflicts of interest. (© 2024 The Author(s).) |
| Databáze: | MEDLINE |
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