Life outside the LINC complex - Do SUN proteins have LINC-independent functions?

Autor: Belaadi N; Altos Labs, Cambridge Institute of Science, Cambridge, UK., Guilluy C; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Jazyk: angličtina
Zdroj: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2024 Aug; Vol. 46 (8), pp. e2400034. Date of Electronic Publication: 2024 May 27.
DOI: 10.1002/bies.202400034
Abstrakt: Sad1 and UNC84 (SUN) and Klarsicht, ANC-1, and Syne homology (KASH) proteins interact at the nuclear periphery to form the linker of nucleoskeleton and cytoskeleton (LINC) complex, spanning the nuclear envelope (NE) and connecting the cytoskeleton with the nuclear interior. It is now well-documented that several cellular functions depend on LINC complex formation, including cell differentiation and migration. Intriguingly, recent studies suggest that SUN proteins participate in cellular processes where their association with KASH proteins may not be required. Building on this recent research, we elaborate on the hypothesis that SUN proteins may perform LINC-independent functions and discuss the modalities that may allow SUN proteins to function at the INM when they are not forming LINC complex.
(© 2024 The Authors. BioEssays published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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