The protective role of commensal gut microbes and their metabolites against bacterial pathogens.

Autor:	Cheng L; Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden.; The Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, China., Correia MSP; Department of Chemistry - BMC, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Higdon SM; Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden., Romero Garcia F; Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden., Tsiara I; Department of Chemistry - BMC, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Joffré E; Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden., Sjöling Å; Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden.; Department of Chemistry and Molecular Biology, University of Gothenburg, Göteborg, Sweden., Boulund F; Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden., Norin EL; Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden., Engstrand L; Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden.; Science for Life Laboratory, Stockholm, Sweden., Globisch D; Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden.; Department of Chemistry - BMC, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Du J; Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden.
Jazyk:	angličtina
Zdroj:	Gut microbes [Gut Microbes] 2024 Jan-Dec; Vol. 16 (1), pp. 2356275. Date of Electronic Publication: 2024 May 26.
DOI:	10.1080/19490976.2024.2356275
Abstrakt:	Multidrug-resistant microorganisms have become a major public health concern around the world. The gut microbiome is a gold mine for bioactive compounds that protect the human body from pathogens. We used a multi-omics approach that integrated whole-genome sequencing (WGS) of 74 commensal gut microbiome isolates with metabolome analysis to discover their metabolic interaction with Salmonella and other antibiotic-resistant pathogens. We evaluated differences in the functional potential of these selected isolates based on WGS annotation profiles. Furthermore, the top altered metabolites in co-culture supernatants of selected commensal gut microbiome isolates were identified including a series of dipeptides and examined for their ability to prevent the growth of various antibiotic-resistant bacteria. Our results provide compelling evidence that the gut microbiome produces metabolites, including the compound class of dipeptides that can potentially be applied for anti-infection medication, especially against antibiotic-resistant pathogens. Our established pipeline for the discovery and validation of bioactive metabolites from the gut microbiome as novel candidates for multidrug-resistant infections represents a new avenue for the discovery of antimicrobial lead structures.
Databáze:	MEDLINE
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