Perioperative Demographic and Laboratory Characteristics of Failed Debridement, Antibiotics, and Implant Retention: Can We Determine Which Patients Will Fail?

Autor: Ashkenazi I; Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, New York, New York; Division of Orthopedic Surgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel., Thomas J; Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, New York, New York., Habibi A; Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, New York, New York., Di Pauli von Treuheim T; Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, New York, New York., Lajam CM; Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, New York, New York., Aggarwal VK; Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, New York, New York., Schwarzkopf R; Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, New York, New York.
Jazyk: angličtina
Zdroj: The Journal of arthroplasty [J Arthroplasty] 2024 Nov; Vol. 39 (11), pp. 2849-2856. Date of Electronic Publication: 2024 May 24.
DOI: 10.1016/j.arth.2024.05.065
Abstrakt: Background: Debridement, antibiotics, and implant retention (DAIR) are the mainstays surgical treatment for acute periprosthetic joint infection (PJI). However, reoperation following DAIR is common and the risk factors for DAIR failure remain unclear. This study aimed to assess the perioperative characteristics of patients who failed initial DAIR treatment.
Methods: A retrospective review was conducted on 83 patients who underwent DAIR for acute PJI within 3 months following index surgery from 2011 to 2022, with a minimum one-year follow-up. Surgical outcomes were categorized using the Musculoskeletal Infection Society outcome reporting tool (Tiers 1 to 4). Patient demographics, laboratory data, and perioperative outcomes were compared between patients who had failed (Tiers 3 and 4) (n = 32) and successful (Tiers 1 and 2) (n = 51) DAIR treatment. Logistic regression was also performed.
Results: After logistic regression, Charlson Comorbidity Index (odds ratio [OR]: 1.57; P = .003), preoperative C-reactive protein (OR: 1.06; P = .014), synovial white blood cell (OR: 1.14; P = .008), and polymorphonuclear cell (PMN%) counts (OR: 1.05; P = .015) were independently associated with failed DAIR. Compared with total hip arthroplasty, total knee arthroplasty patients (OR: 6.08; P = .001) were at increased risk of DAIR failure. The type of organism and time from primary surgery were not correlated with DAIR failure.
Conclusions: Patients who had failed initial DAIR tended to have significantly higher Charlson Comorbidity Index, C-reactive protein, synovial white blood cell, and PMN%. The total knee arthroplasty DAIRs were more likely to fail than the total hip arthroplasty DAIRs. These characteristics should be considered when planning acute PJI management, as certain patients may be at higher risk for DAIR failure and may benefit from other surgical treatments.
Level of Evidence: III.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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