Monitoring of inflammatory blood biomarkers in foals with Rhodococcus Equi pneumonia during antimicrobial treatment.

Autor: Deniz Ö; Department of Internal Medicine, Kastamonu University, Faculty of Veterinary Medicine, 37150, Merkez, Kastaonu, Türkiye., Ekinci G; Department of Internal Medicine, Erciyes University, Faculty of Veterinary Medicine, 38280, Kayseri, Türkiye., Onmaz AC; Department of Internal Medicine, Erciyes University, Faculty of Veterinary Medicine, 38280, Kayseri, Türkiye., Derelli FM; İzmit Stud and Breeding Station of Jockey Club of Türkiye, Kocaeli, Türkiye., Fazio F; Department of Veterinary Sciences, University of Messina, Via Palatucci snc, 98168, Messina, Italy. Electronic address: ffazio@unime.it., Aragona F; Department of Veterinary Sciences, University of Messina, Via Palatucci snc, 98168, Messina, Italy., Hoven RVD; Department of Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases Veterinary University of Vienna, Veterinärplatz 1, A-1210 Vienna, Austria.
Jazyk: angličtina
Zdroj: Journal of equine veterinary science [J Equine Vet Sci] 2024 Jul; Vol. 138, pp. 105103. Date of Electronic Publication: 2024 May 24.
DOI: 10.1016/j.jevs.2024.105103
Abstrakt: Rhodococcus equi (R. equi), a gram-positive facultative intracellular pathogen, is a common cause of pneumonia in foals and represents a major cause of disease and death. The aim of the present study was to investigate the time-depended changes in White Blood Cells (WBC), basophils (Baso), neutrophils (Neu), lymphocytes (Lymf), monocytes (Mon), eosinophils (Eos), platelet (PLT) counts, fibrinogen (Fbg) concentration, interferon (IFN-α, IFN-γ) and interleukins (IL-2 and IL-10) in foals with clinical R. equi pneumonia. The main treatment was with azithromycin-rifampicin for 14 days. Blood was sampled prior to, 7 and 14 days after starting therapy. Treatment was associated with significantly decreased counts of WBC, (25.6 ± 6.7 and 14.2 ± 2,7 × 10 3 /ml), Neu (18.6 ±6.2 and 10.7 ± 3.1 × 10 3 /ml), Mon (1.5 ± 0.5 and 0.9 ± 0.2 × 10 3 /ml) and Fbg (539 ± 124 and 287 ± 26 g/dl) between day 0 and day 14. IL-2 and IL-10 concentrations were significantly increased (P = 0.028, P = 0.013, respectively) after treatment, whereas IFN-α and IFN-γ concentrations were not. The diagnostic potentials of INF-α, INF-γ, IL-2 and IL-10 per se seems not very high, however, the study suggests that the activity change of selected interleukins in the course of the disease may be associated with amelioration. We concluded that patterns of serum concentration changes of INF-α, INF-γ, IL-2 and IL-10 may help in the study of the innate immune response in foals during infection and treatment of R. equi pneumonia.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: