Linking exposure to per- and polyfluoroalkyl substances (PFAS) in house dust and biomonitoring data in eight impacted communities.

Autor: Minucci JM; U.S. EPA, Office of Research and Development, Center for Public Health and Environmental Assessment, United States. Electronic address: minucci.jeffrey@epa.gov., DeLuca NM; U.S. EPA, Office of Research and Development, Center for Public Health and Environmental Assessment, United States., Durant JT; Agency for Toxic Substances and Disease Registry, Office of Community Health Hazard Assessment, United States., Goodwin B; Agency for Toxic Substances and Disease Registry, Office of Community Health Hazard Assessment, United States., Kowalski P; Agency for Toxic Substances and Disease Registry, Office of Community Health Hazard Assessment, United States., Scruton K; Agency for Toxic Substances and Disease Registry, Office of Community Health Hazard Assessment, United States., Thomas K; U.S. EPA, Office of Research and Development, Center for Public Health and Environmental Assessment, United States., Cohen Hubal EA; U.S. EPA, Office of Research and Development, Center for Public Health and Environmental Assessment, United States.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2024 Jun; Vol. 188, pp. 108756. Date of Electronic Publication: 2024 May 17.
DOI: 10.1016/j.envint.2024.108756
Abstrakt: Per- and polyfluoroalkyl substances (PFAS) are widely used in industry and have been linked to various adverse health effects. Communities adjacent to sites where PFAS are manufactured, stored, or used may be at elevated risk. In these impacted communities, significant exposure often occurs through contaminated drinking water, yet less is known about the role of other pathways such as residential exposure through house dust. We analyzed a paired serum and house dust dataset from the Agency for Toxic Substances and Disease Registry's PFAS Exposure Assessments, which sampled eight United States communities with a history of drinking water contamination due to aqueous film forming foam (AFFF) use at nearby military bases. We found that serum PFAS levels of residents were significantly positively associated with the dust PFAS levels in their homes, for three of seven PFAS analyzed, when accounting for site and participant age. We also found that increased dust PFAS levels were associated with a shift in the relative abundance of PFAS in serum towards those chemicals not strongly linked to AFFF contamination, which may suggest household sources. Additionally, we analyzed participant responses to exposure questionnaires to identify factors associated with dust PFAS levels. Dust PFAS levels for some analytes were significantly elevated in households where participants were older and had lived at the home longer, cleaned less frequently, used stain resistant products, and had carpeted living rooms. Our results suggest that residential exposure to PFAS via dust or other indoor pathways may contribute to overall exposure and body burden, even in communities impacted by AFFF contamination of drinking water, and the magnitude of this exposure may also be influenced by demographic, behavioral, and housing factors.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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