[ 18 F]FDG PET/CT is useful in discriminating invasive adenocarcinomas among pure ground-glass nodules: comparison with CT findings-a bicenter retrospective study.

Autor: Moon JW; Department of Radiology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1 Singil-Ro, Yeongdeungpo-Gu, Seoul, 07441, Republic of Korea., Song YH; Department of Radiology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1 Singil-Ro, Yeongdeungpo-Gu, Seoul, 07441, Republic of Korea., Kim YN; Department of Radiology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1 Singil-Ro, Yeongdeungpo-Gu, Seoul, 07441, Republic of Korea., Woo JY; Department of Radiology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1 Singil-Ro, Yeongdeungpo-Gu, Seoul, 07441, Republic of Korea., Son HJ; Department of Nuclear Medicine, Dankook University Medical Center, Cheonan, Chungnam, Republic of Korea., Hwang HS; Department of Nuclear Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro 170 beon-gil, Dongan-gu,Anyang-si, Gyeonggi-do, 14068, Republic of Korea. hshwang@hallym.or.kr., Lee SH; Department of Radiology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1 Singil-Ro, Yeongdeungpo-Gu, Seoul, 07441, Republic of Korea. shlee0021@hallym.or.kr.
Jazyk: angličtina
Zdroj: Annals of nuclear medicine [Ann Nucl Med] 2024 Sep; Vol. 38 (9), pp. 754-762. Date of Electronic Publication: 2024 May 25.
DOI: 10.1007/s12149-024-01944-2
Abstrakt: Purpose: Predicting the malignancy of pure ground-glass nodules (GGNs) using CT is challenging. The optimal role of [ 18 F]FDG PET/CT in this context has not been clarified. We compared the performance of [ 18 F]FDG PET/CT in evaluating GGNs for predicting invasive adenocarcinomas (IACs) with CT.
Methods: From June 2012 to December 2020, we retrospectively enrolled patients with pure GGNs on CT who underwent [ 18 F]FDG PET/CT within 90 days. Overall, 38 patients with 40 ≥ 1-cm GGNs were pathologically confirmed. CT images were analyzed for size, attenuation, uniformity, shape, margin, tumor-lung interface, and internal/surrounding characteristics. Visual [ 18 F]FDG positivity, maximum standardized uptake value (SUV max ), and tissue fraction-corrected SUV max (SUV maxTF ) were evaluated on PET/CT.
Results: The histopathology of the 40 GGNs were: 25 IACs (62.5%), 9 minimally invasive adenocarcinomas (MIA, 22.5%), and 6 adenocarcinomas in situ (AIS, 15.0%). No significant differences were found in CT findings according to histopathology, whereas visual [ 18 F]FDG positivity, SUV max , and SUV maxTF were significantly different (P=0.001, 0.033, and 0.018, respectively). The size, visual [ 18 F]FDG positivity, SUV max , and SUV maxTF showed significant diagnostic performance to predict IACs (area under the curve=0.693, 0.773, 0.717, and 0.723, respectively; P=0.029, 0.001, 0.018, and 0.013, respectively). In the multivariate logistic regression analysis, visual [ 18 F]FDG positivity discriminated IACs among GGNs among various CT and PET findings (P=0.008).
Conclusions: [ 18 F]FDG PET/CT demonstrated superior diagnostic performance compared to CT in differentiating IAC from AIS/MIA among pure GGNs, thus it has the potential to guide the proper management of patients with pure GGNs.
(© 2024. The Author(s), under exclusive licence to The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine.)
Databáze: MEDLINE
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