Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles.

Autor: Filimonova MV; Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia.; Obninsk Institute for Nuclear Power Engineering-Branch of the National Research Nuclear University MEPhI, Obninsk, Russia., Kolmanovich DD; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.; Lebedev Physical Institute, Russian Academy of Sciences, Moscow, Russia., Tikhonowski GV; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia., Petrunya DS; Lebedev Physical Institute, Russian Academy of Sciences, Moscow, Russia. d.petrunya@lebedev.ru.; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia. d.petrunya@lebedev.ru., Kotelnikova PA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Shitova AA; Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia., Soldatova OV; Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia., Filimonov AS; Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia., Rybachuk VA; Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia., Kosachenko AO; Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia., Nikolaev KA; Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia., Demyashkin GA; Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia., Popov AA; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia., Savinov MS; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia., Popov AL; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.; Lebedev Physical Institute, Russian Academy of Sciences, Moscow, Russia., Zelepukin IV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Lipengolts AA; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia.; Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, Moscow, Russia., Shpakova KE; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia.; Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, Moscow, Russia., Kabashin AV; Aix-Marseille University, CNRS, Marseille, France., Koryakin SN; Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia.; Obninsk Institute for Nuclear Power Engineering-Branch of the National Research Nuclear University MEPhI, Obninsk, Russia., Deyev SM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Zavestovskaya IN; Lebedev Physical Institute, Russian Academy of Sciences, Moscow, Russia.; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2024 Jun; Vol. 516 (1), pp. 111-114. Date of Electronic Publication: 2024 May 25.
DOI: 10.1134/S1607672924700819
Abstrakt: Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach.
(© 2024. Pleiades Publishing, Ltd.)
Databáze: MEDLINE
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