| Autor: |
Bigaj-Józefowska MJ; NanoBioMedical Centre, Adam Mickiewicz University in Poznań, Poznań, Poland., Zalewski T; NanoBioMedical Centre, Adam Mickiewicz University in Poznań, Poznań, Poland., Załęski K; NanoBioMedical Centre, Adam Mickiewicz University in Poznań, Poznań, Poland., Coy E; NanoBioMedical Centre, Adam Mickiewicz University in Poznań, Poznań, Poland., Frankowski M; Faculty of Chemistry, Adam Mickiewicz University in Poznań, Poznań, Poland., Mrówczyński R; Faculty of Chemistry, Adam Mickiewicz University in Poznań, Poznań, Poland.; Centre for Advanced Technologies, Adam Mickiewicz University in Poznań, Poznań, Poland., Grześkowiak BF; NanoBioMedical Centre, Adam Mickiewicz University in Poznań, Poznań, Poland. |
| Abstrakt: |
Polydopamine (PDA) stands as a versatile material explored in cancer nanomedicine for its unique properties, offering opportunities for multifunctional drug delivery platforms. This study explores the potential of utilizing a one-pot synthesis to concurrently integrate Fe, Gd and Mn ions into porous PDA-based theranostic drug delivery platforms called Ferritis, Gadolinis and Manganis, respectively. Our investigation spans the morphology, magnetic properties, photothermal characteristics and cytotoxicity profiles of those potent nanoformulations. The obtained structures showcase a spherical morphology, robust magnetic response and promising photothermal behaviour. All of the presented nanoparticles (NPs) display pronounced paramagnetism, revealing contrasting potential for MRI imaging. Relaxivity values, a key determinant of contrast efficacy, demonstrated competitive or superior performance compared to established, used contrasting agents. These nanoformulations also exhibited robust photothermal properties under near infra-red irradiation, showcasing their possible application for photothermal therapy of cancer. Our findings provide insights into the potential of metal-doped PDA NPs for cancer theranostics. |
