Experiment study on focusing pattern prediction of particles in asymmetric contraction-expansion array channel.

Autor: Shi X; School of Chemical Engineering and Technology, Tianjin University, Tianjin, P. R. China., He Q, Tan W; School of Chemical Engineering and Technology, Tianjin University, Tianjin, P. R. China., Lu Y; School of Chemical Engineering and Technology, Tianjin University, Tianjin, P. R. China.; Haihe Laboratory of Sustainable Chemical Transformations, Tianjin, P. R. China., Zhu G; School of Chemical Engineering and Technology, Tianjin University, Tianjin, P. R. China.; Haihe Laboratory of Sustainable Chemical Transformations, Tianjin, P. R. China.
Jazyk: angličtina
Zdroj: Electrophoresis [Electrophoresis] 2024 May 25. Date of Electronic Publication: 2024 May 25.
DOI: 10.1002/elps.202400042
Abstrakt: Contraction-expansion array (CEA) microchannel is a typical structure applied on particle/cell manipulation. The prediction of the particle focusing pattern in CEA microchannel is worthwhile to be investigate deeply. Here, we demonstrated a virtual boundary method by flow field analysis and theoretical derivation. The calculating method of the virtual boundary location, related to the Reynolds number (R e ) and the structure parameter R W , was proposed. Combining the approximate Poiseuille flow pattern based on the virtual boundary method with the simulation results of Dean flow, the main line pattern and the main/lateral lines pattern were predicted and validated in experiments. The transformation from the main line pattern to the main/lateral lines pattern can be facilitated by increasing R e , decreasing R W , and decreasing α. An empirical formula was derived to characterize the critical condition of the transformation. The virtual boundary method can provide a guidance for asymmetric CEA channel design and contribute to the widespread application of microfluidic particle focusing.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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