Molecular Biomarkers and Signaling Pathways of Cancer Stem Cells in Colorectal Cancer.

Autor:	Omran MM; Biochemistry Division, Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt., Fouda MS; Biochemistry Division, Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt., Mekkawy SA; Molecular Biotechnology Program, Faculty of Science, Helwan University, Cairo, Egypt., Tabll AA; Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Dokki, Egypt.; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt., Abdelaziz AG; Biochemistry Division, Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt., Omran AM; Clinical Pharma Program, Faculty of Pharmacy, Delta University, Dakahlia, Egypt., Emran TM; Clinical Pathology Department, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt.
Jazyk:	angličtina
Zdroj:	Technology in cancer research & treatment [Technol Cancer Res Treat] 2024 Jan-Dec; Vol. 23, pp. 15330338241254061.
DOI:	10.1177/15330338241254061
Abstrakt:	Colorectal cancer (CRC) is the third most frequently found cancer in the world, and it is frequently discovered when it is already far along in its development. About 20% of cases of CRC are metastatic and incurable. There is more and more evidence that colorectal cancer stem cells (CCSCs), which are in charge of tumor growth, recurrence, and resistance to treatment, are what make CRC so different. Because we know more about stem cell biology, we quickly learned about the molecular processes and possible cross-talk between signaling pathways that affect the balance of cells in the gut and cancer. Wnt, Notch, TGF-β, and Hedgehog are examples of signaling pathway members whose genes may change to produce CCSCs. These genes control self-renewal and pluripotency in SCs and then decide the function and phenotype of CCSCs. However, in terms of their ability to create tumors and susceptibility to chemotherapeutic drugs, CSCs differ from normal stem cells and the bulk of tumor cells. This may be the reason for the higher rate of cancer recurrence in patients who underwent both surgery and chemotherapy treatment. Scientists have found that a group of uncontrolled miRNAs related to CCSCs affect stemness properties. These miRNAs control CCSC functions like changing the expression of cell cycle genes, metastasis, and drug resistance mechanisms. CCSC-related miRNAs mostly control signal pathways that are known to be important for CCSC biology. The biomarkers (CD markers and miRNA) for CCSCs and their diagnostic roles are the main topics of this review study. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu