Mechanical control of antigen detection and discrimination by T and B cell receptors.

Autor:	Rogers J; Department of Chemistry, Emory University, Atlanta, Georgia., Bajur AT; Department of Physics, King's College London, London, United Kingdom; Randall Centre for Cell and Molecular Biophysics, King's College London, London, United Kingdom., Salaita K; Department of Chemistry, Emory University, Atlanta, Georgia; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia. Electronic address: k.salaita@emory.edu., Spillane KM; Department of Physics, King's College London, London, United Kingdom; Randall Centre for Cell and Molecular Biophysics, King's College London, London, United Kingdom; Department of Life Sciences, Imperial College London, London, United Kingdom. Electronic address: k.spillane@imperial.ac.uk.
Jazyk:	angličtina
Zdroj:	Biophysical journal [Biophys J] 2024 Aug 06; Vol. 123 (15), pp. 2234-2255. Date of Electronic Publication: 2024 May 23.
DOI:	10.1016/j.bpj.2024.05.020
Abstrakt:	The adaptive immune response is orchestrated by just two cell types, T cells and B cells. Both cells possess the remarkable ability to recognize virtually any antigen through their respective antigen receptors-the T cell receptor (TCR) and B cell receptor (BCR). Despite extensive investigations into the biochemical signaling events triggered by antigen recognition in these cells, our ability to predict or control the outcome of T and B cell activation remains elusive. This challenge is compounded by the sensitivity of T and B cells to the biophysical properties of antigens and the cells presenting them-a phenomenon we are just beginning to understand. Recent insights underscore the central role of mechanical forces in this process, governing the conformation, signaling activity, and spatial organization of TCRs and BCRs within the cell membrane, ultimately eliciting distinct cellular responses. Traditionally, T cells and B cells have been studied independently, with researchers working in parallel to decipher the mechanisms of activation. While these investigations have unveiled many overlaps in how these cell types sense and respond to antigens, notable differences exist. To fully grasp their biology and harness it for therapeutic purposes, these distinctions must be considered. This review compares and contrasts the TCR and BCR, placing emphasis on the role of mechanical force in regulating the activity of both receptors to shape cellular and humoral adaptive immune responses. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Biophysical Society. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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