| Autor: |
Petrová M; Institute of Parasitology, Slovak Academy of Sciences, 040 01 Kosice, Slovakia., Hurníková Z; Institute of Parasitology, Slovak Academy of Sciences, 040 01 Kosice, Slovakia., Lauková A; Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, 040 01 Kosice, Slovakia., Dvorožňáková E; Institute of Parasitology, Slovak Academy of Sciences, 040 01 Kosice, Slovakia. |
| Jazyk: |
angličtina |
| Zdroj: |
Microorganisms [Microorganisms] 2024 May 01; Vol. 12 (5). Date of Electronic Publication: 2024 May 01. |
| DOI: |
10.3390/microorganisms12050923 |
| Abstrakt: |
Beneficial/probiotic strains protect the host from pathogens by competitive displacement and production of antibacterial substances, i.e., bacteriocins. The antiparasitic potential of bacteriocins/enterocins and their producing strains in experimental murine trichinellosis were tested as a new therapeutic strategy. Enterocin M and Durancin-like and their producers Enterococcus faecium CCM8558 and Enterococcus durans ED26E/7 were administered daily to mice that were challenged with Trichinella spiralis . Our study confirmed the antiparasitic effect of enterocins/enterococci, which reduced the number of adults in the intestine (Enterocin M-43.8%, E. faecium CCM8558-54.5%, Durancin-like-16.4%, E. durans ED26E/7-35.7%), suppressed the Trichinella reproductive capacity ex vivo (Enterocin M-61%, E. faecium CCM8558-74%, Durancin-like-38%, E. durans ED26E/7-66%), and reduced the number of muscle larvae (Enterocin M-39.6%, E. faecium CCM8558-55.7%, Durancin-like-15%, E. durans ED26E/7-36.3%). The direct effect of enterocins on Trichinella fecundity was documented by an in vitro test in which Durancin-like showed a comparable reducing effect to Enterocin M (40-60%) in contrast to the ex vivo test. The reducing activity of T.spiralis infection induced by Enterocin M was comparable to its strain E. faecium CCM8558; Durancin-like showed lower antiparasitic activity than its producer E. durans ED26E/7. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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