A Clinical Study of Urine Amino Acids in Children with Autism Spectrum Disorder.

Autor: Anastasescu CM; Hospital of Neuropsychiatry Craiova, Children Mental Health Center, 200349 Craiova, Romania., Gheorman V; Department 3 Medical Semiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Popescu F; Pharmacology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Stepan MD; Department of Infant Care-Pediatrics-Neonatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Stoicănescu EC; Pediatry Department, Emergency Clinical Hospital Râmnicu Vâlcea, 200300 Râmnicu Vâlcea, Romania., Gheorman V; Department of Psychiatry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Udriștoiu I; Department of Psychiatry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2024 May 15; Vol. 14 (5). Date of Electronic Publication: 2024 May 15.
DOI: 10.3390/life14050629
Abstrakt: Amino acids are organic compounds that enter the protein structure, being involved in the proper functioning of the body. The role of amino acids in the onset of autism spectrum disorder (ASD) is yet to be established. Our aim was to identify correlations between urine amino acids and their derivatives and ASD.
Methods: We designed a case-control study that consisted of 75 boys and girls, aged between 2 and 12 years. For amino acid profile, we used urine samples that were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Results: Descriptive analysis showed higher values for glutamine, hydroxyproline, tyrosine, aspartic acid, and tryptophan and lower values for serine in the autism group than in the control group. Also, we found that boys with autism had higher values than the boys in the control group for serine, threonine, and aspartic acid. For girls from both groups, we did not find statistically significant values. In terms of age groups, we found significantly higher values for histidine, threonine, valine, methionine, aspartic acid, glutamic acid, alpha amino-adipic acid, sarcosine, alanine, and beta-alanine and significantly lower values for proline for both the autism and control groups under 5 years.
Conclusions: The findings of this study support the assumption that amino acids may have a role in the expression of ASD.
Databáze: MEDLINE
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