| Autor: |
Han M; Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.; Chaum Life Center, CHA University School of Medicine, Seoul 06062, Republic of Korea., Chang T; Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea., Chun HR; Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea., Jo S; Institute of Health and Environment, Seoul National University, Seoul 08826, Republic of Korea., Jo Y; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea., Yu DH; Big Data Department, Health Insurance Review and Assessment Service, Wonju 26465, Republic of Korea., Yoo S; Healthcare ICT Research Center, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea., Cho SI; Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.; Institute of Health and Environment, Seoul National University, Seoul 08826, Republic of Korea. |
| Abstrakt: |
Background/Objectives: There have been widespread reports of persistent symptoms in both children and adults after SARS-CoV-2 infection, giving rise to debates on whether it should be regarded as a separate clinical entity from other postviral syndromes. This study aimed to characterize the clinical presentation of post-acute symptoms and conditions in the Korean pediatric and adult populations. Methods : A retrospective analysis was performed using a national, population-based database, which was encoded using the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). We compared individuals diagnosed with SARS-CoV-2 to those diagnosed with influenza, focusing on the risk of developing prespecified symptoms and conditions commonly associated with the post-acute sequelae of COVID-19. Results : Propensity score matching yielded 1,656 adult and 343 pediatric SARS-CoV-2 and influenza pairs. Ninety days after diagnosis, no symptoms were found to have elevated risk in either adults or children when compared with influenza controls. Conversely, at 1 day after diagnosis, adults with SARS-CoV-2 exhibited a significantly higher risk of developing abnormal liver function tests, cardiorespiratory symptoms, constipation, cough, thrombophlebitis/thromboembolism, and pneumonia. In contrast, children diagnosed with SARS-CoV-2 did not show an increased risk for any symptoms during either acute or post-acute phases. Conclusions : In the acute phase after infection, SARS-CoV-2 is associated with an elevated risk of certain symptoms in adults. The risk of developing post-acute COVID-19 sequelae is not significantly different from that of having postviral symptoms in children in both the acute and post-acute phases, and in adults in the post-acute phase. These observations warrant further validation through studies, including the severity of initial illness, vaccination status, and variant types. |
