Navigating the Maze: Exploring Non-Oncological Complexities in Non-Small-Cell Lung Cancer.

Autor: Marghescu AȘ; Pathology Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Research, Marius Nasta Institute of Pneumophthisiology, 050159 Bucharest, Romania., Vlăsceanu S; Physiology Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Thoracic Surgery, Marius Nasta Institute of Pneumophthisiology, 050159 Bucharest, Romania., Preda M; Department of Microbiology, Parasitology and Virology, Faculty of Midwives and Nursing, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Clinical Laboratory of Medical Microbiology, Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania., Țigău M; Department of Research, Marius Nasta Institute of Pneumophthisiology, 050159 Bucharest, Romania., Dumitrache-Rujinski Ș; Pulmonology Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Pulmonology Department, Marius Nasta Institute of Pneumophthisiology, 050159 Bucharest, Romania., Leonte DG; Pathology Department, Marius Nasta Institute of Pneumophthisiology, 050159 Bucharest, Romania., Măgheran ED; Pathology Department, Marius Nasta Institute of Pneumophthisiology, 050159 Bucharest, Romania., Tudor A; Pathology Department, Marius Nasta Institute of Pneumophthisiology, 050159 Bucharest, Romania., Bădărău IA; Physiology Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania., Georgescu L; Department of Research, Marius Nasta Institute of Pneumophthisiology, 050159 Bucharest, Romania., Costache M; Pathology Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Pathology Department, University Emergency Hospital Bucharest, 050098 Bucharest, Romania.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 May 16; Vol. 16 (10). Date of Electronic Publication: 2024 May 16.
DOI: 10.3390/cancers16101903
Abstrakt: Pulmonary oncological pathologies are an important public health problem and the association with other pulmonary lesions may pose difficulties in diagnosis and staging or require different treatment options. To address this complexity, we conducted a retrospective observational study at the Marius Nasta Institute of Pneumophthisiology, Bucharest, Romania. Our study focused on patients admitted in 2019 with non-small-cell lung carcinoma and associated pulmonary lesions identified through surgical resection specimens. Among the 314 included patients, multiple pulmonary nodules were observed on macroscopic examination, with 12% (N = 37) exhibiting nonmalignant etiologies upon microscopic examination. These findings underscore the challenge of preoperative staging. Patients with coexisting nonmalignant lesions were similar in age, smoking habits, and professional or environmental exposure by comparison with those who presented only malignant lesions. The presentation of coexisting malignant and nonmalignant lesions may pose difficulties in diagnosing and staging pulmonary cancer.
Competing Interests: The authors declare no conflicts of interest.
Databáze: MEDLINE
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