| Autor: |
Nguyen N; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA., Woodside DB; Centre for Mental Health, University Health Network, Toronto, ON M5G 2C4, Canada., Lam E; Centre for Mental Health, University Health Network, Toronto, ON M5G 2C4, Canada., Quehenberger O; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA., German JB; Department of Food Science & Technology, University of California, Davis, Davis, CA 95616, USA., Shih PB; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA. |
| Abstrakt: |
Disordered eating behavior differs between the restricting subtype (AN-R) and the binging and purging subtype (AN-BP) of anorexia nervosa (AN). Yet, little is known about how these differences impact fatty acid (FA) dysregulation in AN. To address this question, we analyzed 26 FAs and 7 FA lipogenic enzymes (4 desaturases and 3 elongases) in 96 women: 25 AN-R, 25 AN-BP, and 46 healthy control women. Our goal was to assess subtype-specific patterns. Lauric acid was significantly higher in AN-BP than in AN-R at the fasting timepoint ( p = 0.038) and displayed significantly different postprandial changes 2 h after eating. AN-R displayed significantly higher levels of n-3 alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid (EPA), docosapentaenoic acid, and n-6 linoleic acid and gamma-linolenic acid compared to controls. AN-BP showed elevated EPA and saturated lauric acid compared to controls. Higher EPA was associated with elevated anxiety in AN-R ( p = 0.035) but was linked to lower anxiety in AN-BP ( p = 0.043). These findings suggest distinct disordered eating behaviors in AN subtypes contribute to lipid dysregulation and eating disorder comorbidities. A personalized dietary intervention may improve lipid dysregulation and enhance treatment effectiveness for AN. |
