Agastache Species (Lamiaceae) as a Valuable Source of Volatile Compounds: GC-MS Profiling and Investigation of In Vitro Antibacterial and Cytotoxic Activities.

Autor: Nechita MA; Department of Pharmacognosy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Ion Creangă Street 12, 400010 Cluj-Napoca, Romania., Pralea IE; Department of Proteomics and Metabolomics, Research Center for Advanced Medicine-MedFuture, 'Iuliu Hațieganu' University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Street 4-6, 400349 Cluj-Napoca, Romania., Țigu AB; Department of Translational Medicine, Research Center for Advanced Medicine-MedFuture, 'Iuliu Hațieganu' University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania., Iuga CA; Department of Proteomics and Metabolomics, Research Center for Advanced Medicine-MedFuture, 'Iuliu Hațieganu' University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Street 4-6, 400349 Cluj-Napoca, Romania.; Department of Pharmaceutical Analysis, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania., Pop CR; Department of Food Science, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Calea Florești Street 64, 400509 Cluj-Napoca, Romania., Gál E; Department of Chemistry and Chemical Engineering, Hungarian Line, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, Arany János Street 11, 400028 Cluj-Napoca, Romania., Vârban R; Department of Crop Science, Faculty of Agriculture, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Calea Mănăștur Street 3-5, 400372 Cluj-Napoca, Romania., Nechita VI; Department of Medical Informatics and Biostatistics, Faculty of Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania., Oniga O; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Victor Babeș Street 41, 400010 Cluj-Napoca, Romania., Toiu A; Department of Pharmacognosy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Ion Creangă Street 12, 400010 Cluj-Napoca, Romania., Benedec D; Department of Pharmacognosy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Ion Creangă Street 12, 400010 Cluj-Napoca, Romania., Hanganu D; Department of Pharmacognosy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Ion Creangă Street 12, 400010 Cluj-Napoca, Romania., Oniga I; Department of Pharmacognosy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Ion Creangă Street 12, 400010 Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2024 May 14; Vol. 25 (10). Date of Electronic Publication: 2024 May 14.
DOI: 10.3390/ijms25105366
Abstrakt: Nowadays, there is an increasing interest in the study of medicinal and aromatic plants, due to their therapeutic properties that correlate with the presence of different active compounds. Agastache species (sp.) are aromatic plants that belong to the Lamiaceae family, originating from North America and East Asia. The present study aimed to evaluate the composition of essential oils (EOs) obtained from different Romanian cultivated Agastache sp. and to investigate their antibacterial and cytotoxic activities. The gas chromatography-mass spectrometry (GC-MS) screening revealed that menthone was the dominant constituent of A. foeniculum (31.58%), A. rugosa (39.60%) and A. rugosa 'After Eight' (39.76%) EOs, while estragole was the major constituent of A. foeniculum "Aromat de Buzău" (63.27%) and A. mexicana (41.66%) EOs. The investigation of the antiproliferative effect showed that A. rugosa and A. foeniculum "Aromat de Buzău" EOs had significant cytotoxic activity on MDA-MB-231 and HEPG2 tumour cell lines, with the most promising effect on the MDA-MB-231 breast cancer cell line for A. foeniculum "Aromat de Buzău" EO (IC 50 = 203.70 ± 0.24 μg/mL). Regarding the antibacterial activity, A. rugosa EO was most active against E. coli (8.91 ± 3.27 μL/mL) and S. aureus (10.80 ± 0.00 μL/mL). To the best of our knowledge, this is the first report on the cytotoxic effect of Agastache sp. EOs on MDA-MB-231, HCT116 and HEPG2 tumour cell lines. The results of our study provide new and promising information for the subsequent in vivo study of the pharmacological properties of Agastache sp. essential oils.
Databáze: MEDLINE
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