Sacral Bioneuromodulation: The Role of Bone Marrow Aspirate in Spinal Cord Injuries.

Autor: Lana JF; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil.; Clinical Research, Anna Vitória Lana Institute (IAVL), Indaiatuba 13334-170, SP, Brazil.; Medical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, Brazil., Navani A; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil.; Medical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, Brazil.; Comprehensive Spine & Sports Center, Campbell, CA 95008, USA., Jeyaraman M; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil.; Department of Orthopaedics, ACS Medical College and Hospital, Chennai 600077, Tamil Nadu, India., Santos N; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Pires L; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Santos GS; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Rodrigues IJ; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Santos D; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Mosaner T; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Azzini G; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., da Fonseca LF; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil.; Medical School, Federal University of São Paulo (UNIFESP), São Paulo 04024-002, SP, Brazil., de Macedo AP; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Huber SC; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., de Moraes Ferreira Jorge D; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Purita J; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil.; Medical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, Brazil.
Jazyk: angličtina
Zdroj: Bioengineering (Basel, Switzerland) [Bioengineering (Basel)] 2024 May 06; Vol. 11 (5). Date of Electronic Publication: 2024 May 06.
DOI: 10.3390/bioengineering11050461
Abstrakt: Spinal cord injury (SCI) represents a severe trauma to the nervous system, leading to significant neurological damage, chronic inflammation, and persistent neuropathic pain. Current treatments, including pharmacotherapy, immobilization, physical therapy, and surgical interventions, often fall short in fully addressing the underlying pathophysiology and resultant disabilities. Emerging research in the field of regenerative medicine has introduced innovative approaches such as autologous orthobiologic therapies, with bone marrow aspirate (BMA) being particularly notable for its regenerative and anti-inflammatory properties. This review focuses on the potential of BMA to modulate inflammatory pathways, enhance tissue regeneration, and restore neurological function disrupted by SCI. We hypothesize that BMA's bioactive components may stimulate reparative processes at the cellular level, particularly when applied at strategic sites like the sacral hiatus to influence lumbar centers and higher neurological structures. By exploring the mechanisms through which BMA influences spinal repair, this review aims to establish a foundation for its application in clinical settings, potentially offering a transformative approach to SCI management that extends beyond symptomatic relief to promoting functional recovery.
Databáze: MEDLINE
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