Quantitative assessment of intervortex anastomosis in central serous chorioretinopathy and fellow eyes: Does the size of anastomotic vessels matter for the diagnosis?

Autor: Demirel S; Department of Ophthalmology, Ankara University School of Medicine, Vehbi Koç Eye Hospital, Mamak Street, Dikimevi, Ankara, Turkey. drsibeldemireltr@yahoo.com.tr., Ayaz RE; Department of Ophthalmology, Marmara University Pendik Training and Research Hospital, Ankara, Turkey., Yanık Ö; Department of Ophthalmology, Ankara University School of Medicine, Vehbi Koç Eye Hospital, Mamak Street, Dikimevi, Ankara, Turkey., Batıoğlu F; Department of Ophthalmology, Ankara University School of Medicine, Vehbi Koç Eye Hospital, Mamak Street, Dikimevi, Ankara, Turkey., Özmert E; Department of Ophthalmology, Ankara University School of Medicine, Vehbi Koç Eye Hospital, Mamak Street, Dikimevi, Ankara, Turkey., Iovino C; Eye Clinic, Multidisciplinary Department of Medical Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy., Chhablani J; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Jazyk: angličtina
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2024 Nov; Vol. 262 (11), pp. 3509-3517. Date of Electronic Publication: 2024 May 24.
DOI: 10.1007/s00417-024-06517-7
Abstrakt: Purpose: To evaluate the frequency and size of intervortex anastomosis at the posterior pole on en-face spectral domain optical coherence tomography (SD-OCT) images in central serous chorioretinopathy (CSC) cases and their fellow eyes and its associations with choroidal morphology.
Methods: Sixty-five treatment-naive eyes of 65 patients with CSC, 65 fellow eyes, and 55 eyes of healthy age-matched participants were included. The presence of intervortex anastomosis at the watershed zone and asymmetry of the choroidal vessels between the superior and inferior macula were evaluated using 6 × 6 mm en-face SD-OCT. The diameter of the widest Haller vessel and the diameter of the widest anastomotic Haller vessel passing through the watershed zone were measured on en-face SD-OCT images. The choroidal vascularity index (CVI) was assessed using ImageJ software.
Results: Intervortex vein anastomosis on the horizontal watershed zone was detected in 75.4% diseased eyes, 61.5% in fellow eyes, and 36.4% in healthy age-matched controls (p < 0.001). The mean CVI was significantly higher in both diseased (74.3 ± 2.3%) and fellow (73.8 ± 2.2%) eyes of CSC cases than in healthy controls (72.5 ± 2.3%) (p = 0.002, p = 0.013, respectively). In the cases with intervortex vein anastomosis, the diameter of the widest anastomotic Haller vessel passing through the watershed zone was 0.40 ± 0.10 mm in diseased eyes, 0.35 ± 0.11 mm in fellow eyes, and 0.30 ± 0.09 mm in healthy age-matched controls (p = 0.001).
Conclusions: Intervortex anastomosis might be seen as a variation in normal eyes, however, its frequency and the size of anastomotic vessels are significant higher in not only CSC but also in fellow eyes.
Competing Interests: Declarations. Compliance with ethical standards: All procedures performed in our study involving human participants were in accordance with the ethical standards of the institutional ethics committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ethical approval for the study was obtained from the Ankara University Faculty of Medicine Ethics Committee (decision number: I05-295–22; date: 27.05.2022). Informed consent: Informed consent was obtained from all individual participants included in the study. Conflict of interest: The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Other financial disclosures: S. Demirel, Consultant fee, Honorarium for lecturing (Novartis, Bayer, Abbvie, Alcon, Baush & Lomb); R. Eroğlu Ayaz, None; Ö. Yanık, None; F. Batıoğlu, Consultant fee, Honorarium for lecturing (Novartis, Bayer, Abbvie, Thea, Baush & Lomb); E. Özmert, Consultant fee, Honorarium for lecturing (Novartis, Bayer, Abbvie); C. Iovino, None; J. Chhablani, Abbvie, Novartis, Salutaris, OD-OS, Erasca, Baush & Lomb, Iveric Bio.
(© 2024. The Author(s).)
Databáze: MEDLINE
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