Rose geranium in sesame oil nasal spray to improve nasal vestibulitis symptoms: a randomized controlled trial.

Autor: Cathcart-Rake EJ; Department of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. Cathcart-Rake.Elizabeth@mayo.edu., Steinert K; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Smith D; Department of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Lewis-Peters S; Department of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Giridhar K; Department of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Novotny P; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Dauer D; Essentia Health Community Cancer Research Program, 523 North Third Street, Brainerd, MN, USA., O'Connor A; Department of Medical Oncology, Mayo Clinic - Mankato, Mankato, MN, USA., Thomé S; Department of Medical Oncology, Mayo Clinic - Mankato, Mankato, MN, USA., Erickson MK; Essentia Health Cancer Center, 420 East First St, Duluth, MN, USA., Friday BB; Essentia Health Cancer Center, 420 East First St, Duluth, MN, USA., Loprinzi CL; Department of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Jazyk: angličtina
Zdroj: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2024 May 24; Vol. 32 (6), pp. 379. Date of Electronic Publication: 2024 May 24.
DOI: 10.1007/s00520-024-08580-6
Abstrakt: Purpose: The purpose of this phase III randomized double-blinded controlled trial was to investigate the efficacy of a rose geranium in sesame oil (RG) nasal spray compared with an isotonic saline (IS) nasal spray for alleviating nasal vestibulitis symptoms among patients undergoing chemotherapy.
Methods: Patients undergoing active chemotherapy who reported associated nasal symptoms were randomized 1:1 to receive RG or IS, administered twice daily for 2 weeks. Consenting participants completed nasal symptom questionnaires at baseline and then weekly while on treatment. The proportion of patients experiencing improvements in their nasal symptoms 2 weeks after initiating the nasal spray, using a six-point global impression of change score, was estimated within and between each randomized arm, and compared between arms, using Fisher's exact test. The estimated odds ratio was determined (95% confidence interval).
Results: One hundred and six patients consented to this study; 43 participants in the RG arm and 41 in the IS arm were evaluable for the primary endpoint. Participants had a mean age of 57.8 years (SD 13.9). Demographic characteristics and baseline nasal symptoms were similar between arms. Of the evaluable participants who received RG, 67.4% reported improved nasal symptoms, compared with 36.6% of the participants who received IS (P = 0.009). Adverse events were sparse and did not differ between arms.
Conclusion: Rose geranium in sesame oil significantly improves nasal vestibulitis symptoms among patients undergoing chemotherapy.
Trial Registration: NCT04620369.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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