Novel strategies for drug repurposing.
| Autor: | Takundwa MM; Synthetic Nanobiotechnology and Biomachines, Synthetic Biology and Precision Medicine Centre, Future Production Chemicals Cluster, Council for Scientific and Industrial Research, Pretoria, South Africa., Thimiri Govinda Raj DB; Synthetic Nanobiotechnology and Biomachines, Synthetic Biology and Precision Medicine Centre, Future Production Chemicals Cluster, Council for Scientific and Industrial Research, Pretoria, South Africa. Electronic address: dgovindaraj@csir.co.za. |
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| Jazyk: | angličtina |
| Zdroj: | Progress in molecular biology and translational science [Prog Mol Biol Transl Sci] 2024; Vol. 205, pp. 9-21. Date of Electronic Publication: 2024 Mar 22. |
| DOI: | 10.1016/bs.pmbts.2024.03.021 |
| Abstrakt: | Synthetic biology, precision medicine, and nanobiotechnology are the three main emerging areas that drive translational innovation toward commercialization. There are several strategies used in precision medicine and drug repurposing is one of the key approaches as it addresses the challenges in drug discovery (high cost and time). Here, we provide a perspective on various new approaches to drug repurposing for cancer precision medicine. We report here our optimized wound healing methodology that can be used to validate drug sensitivity and drug repurposing. Using HeLa as our benchmark, we demonstrated that the assay can be applied to identify drugs that limit cell proliferation. From a future perspective, this assay can be expanded to ex vivo culturing of solid tumors in 2D culture and leukemia in 3D culture. (Copyright © 2024. Published by Elsevier Inc.) |
| Databáze: | MEDLINE |
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