Epidemiology of fractures in adults of African ancestry with diabetes mellitus: A systematic review and meta-analysis.

Autor: Zhang SC; Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia., Makebeh T; ZEZE co, Yaoundé, Cameroon., Mesinovic J; Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Australia., Djopseu K; ZEZE co, Yaoundé, Cameroon., Martin C; School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia., Lui LY; Research Institute, California Pacific Medical Center, San Francisco, CA, USA., Cawthon PM; Research Institute, California Pacific Medical Center, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA., Schneider ALC; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Zmuda JM; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Strotmeyer ES; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Schafer A; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA; Endocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Ebeling PR; Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia; Department of Endocrinology, Monash Health, Clayton, Victoria, Australia., Zebaze RM; Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia; Department of Endocrinology, Monash Health, Clayton, Victoria, Australia. Electronic address: roger.zebaze@monash.edu.
Jazyk: angličtina
Zdroj: Bone [Bone] 2024 Aug; Vol. 185, pp. 117133. Date of Electronic Publication: 2024 May 22.
DOI: 10.1016/j.bone.2024.117133
Abstrakt: Diabetes mellitus (DM) is associated with increased fracture risk in White adults. However, the impact of DM on fractures in Black adults is unknown. This systematic review and meta-analysis investigated the association between DM and fractures in adults of African ancestry. MEDLINE, Scopus, CINAHL and Embase databases were searched from their inception up to November 2023 for all studies in the English language investigating the epidemiology of fractures (prevalence, incidence, or risk) in Black men and women (age ≥ 18 years) with type 1 or type 2 DM. Effect sizes for prevalence of previous fractures (%) and incident fracture risk (hazard ratio [HR]) were calculated using a random-effects model on Stata (version 18.0). There were 13 eligible studies, of which 12 were conducted in Black adults from the United States, while one was conducted in adults of West African ancestry from Trinidad and Tobago. We found no fracture data in Black adults with DM living in Africa. Five studies were included in a meta-analysis of incident fracture risk, reporting data from 2926 Black and 6531 White adults with DM. There was increased risk of fractures in Black adults with DM compared to non-DM (HR = 1.65; 95 % confidence interval [CI]: 1.14, 2.39). The risk of fractures was also higher in White adults with DM compared to non-DM (HR = 1.31; 95 % CI: 1.06, 1.61) among these studies. Five studies were included in a meta-analysis of fracture prevalence, of which three also reported fracture prevalence in White adults. There were 175 previous fractures among 993 Black adults with DM and 384 previous fractures among 1467 White adults with DM, with a pooled prevalence of 17.5 % (95 % CI: 15.4, 19.6) and 25.8 % (95 % CI: 4.8, 46.8), respectively. Our results indicate a high burden of fractures in Black adults with DM.
Competing Interests: Declaration of competing interest The authors declare that they have no conflict/s of interest. There was no internal and/or external source of funding for the present study.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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