Ferroptosis: A new strategy for targeting Alzheimer's disease.

Autor: Qiang RR; School of Medicine, Yan'an University, Yan'an, China., Xiang Y; College of Physical Education, Yan'an University, Shaanxi, 716000, China., Zhang L; School of Medicine, Yan'an University, Yan'an, China., Bai XY; School of Medicine, Yan'an University, Yan'an, China., Zhang D; School of Medicine, Yan'an University, Yan'an, China., Li YJ; School of Medicine, Yan'an University, Yan'an, China., Yang YL; School of Medicine, Yan'an University, Yan'an, China., Liu XL; School of Medicine, Yan'an University, Yan'an, China. Electronic address: liuxiaolong@yau.edu.cn.
Jazyk: angličtina
Zdroj: Neurochemistry international [Neurochem Int] 2024 Sep; Vol. 178, pp. 105773. Date of Electronic Publication: 2024 May 23.
DOI: 10.1016/j.neuint.2024.105773
Abstrakt: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a complex pathogenesis, which involves the formation of amyloid plaques and neurofibrillary tangles. Many recent studies have revealed a close association between ferroptosis and the pathogenesis of AD. Factors such as ferroptosis-associated iron overload, lipid peroxidation, disturbances in redox homeostasis, and accumulation of reactive oxygen species have been found to contribute to the pathological progression of AD. In this review, we explore the mechanisms underlying ferroptosis, describe the link between ferroptosis and AD, and examine the reported efficacy of ferroptosis inhibitors in treating AD. Finally, we discuss the potential challenges to ferroptosis inhibitors use in the clinic, enabling their faster use in clinical treatment.
Competing Interests: Declaration of competing interest No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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