Effects of gallic acid and physical training on liver damage, force, and anxiety in obese mice: Hepatic modulation of Sestrin 2 (SESN2) and PGC-α expression.

Autor: Sousa JN; Laboratory of Health Science, Post graduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil., Sousa BVO; Laboratory of Health Science, Post graduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil., Santos EPD; Laboratory of Health Science, Post graduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil., Ribeiro GHM; Laboratory of Health Science, Post graduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil; Institute of Agricultural Sciences (ICA), Post graduate Program in Food and Health, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil., Pereira APM; Laboratory of Health Science, Post graduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil; Institute of Agricultural Sciences (ICA), Post graduate Program in Food and Health, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil., Guimarães VHD; Laboratory of Health Science, Post graduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil., Queiroz LDRP; Laboratory of Health Science, Post graduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil., Motta-Santos D; Sports Department, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Farias LC; Laboratory of Health Science, Post graduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil., Guimarães ALS; Laboratory of Health Science, Post graduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil., de Paula AMB; Laboratory of Health Science, Post graduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil., Santos SHS; Laboratory of Health Science, Post graduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil; Institute of Agricultural Sciences (ICA), Post graduate Program in Food and Health, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil. Electronic address: sergiosousas@hotmail.com.
Jazyk: angličtina
Zdroj: Gene [Gene] 2024 Oct 30; Vol. 926, pp. 148606. Date of Electronic Publication: 2024 May 23.
DOI: 10.1016/j.gene.2024.148606
Abstrakt: Obesity and overweight are multifactorial diseases affecting more than one-third of the world's population. Physical inactivity contributes to a positive energy balance and the onset of obesity. Exercise combined with a balanced diet is an effective non-pharmacological strategy to improve obesity-related disorders. Gallic acid (GA), is a natural endogenous polyphenol found in a variety of fruits, vegetables, and wines, with beneficial effects on energetic homeostasis. The present study aims to investigate the effects of exercise training on obese mice supplemented with GA. Animal experimentation was performed with male Swiss mice divided into five groups: ST (standard control), HFD (obese control), HFD + GA (GA supplement), HFD + Trained (training), and HFD + GA + Trained (GA and training). The groups are treated for eight weeks with 200 mg/kg/body weight of the feed compound and, if applicable, physical training. The main findings of the present study show that GA supplementation improves liver fat, body weight, adiposity, and plasma insulin levels. In addition, animals treated with the GA and a physical training program demonstrate reduced levels of anxiety. Gene expression analyses show that Sesn2 is activated via PGC-1α independent of the GATOR2 protein, which is activated by GA in the context of physical activity. These data are corroborated by molecular docking analysis, demonstrating the interaction of GA with GATOR2. The present study contributes to understanding the metabolic effects of GA and physical training and demonstrates a new hepatic mechanism of action via Sestrin 2 and PGC-1α.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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