Exposure to maternal cannabis use disorder and risk of autism spectrum disorder in offspring: A data linkage cohort study.

Autor: Tadesse AW; School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia; Dream Science and Technology College, Dessie 1466, Amhara region, Ethiopia; Department of Public Health, College of Medicine and Health Sciences, Samara University 132, Semera, Ethiopia. Electronic address: tadesse.woday@postgrad.curtin.edu.au., Ayano G; School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia., Dachew BA; School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia., Betts K; School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia., Alati R; School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia; Institute for Social Sciences Research, The University of Queensland, 80 Meier's Rd, Indooroopilly, QLD, 4068, Australia.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2024 Jul; Vol. 337, pp. 115971. Date of Electronic Publication: 2024 May 20.
DOI: 10.1016/j.psychres.2024.115971
Abstrakt: This study aimed to investigate the association between pre-pregnancy, prenatal and perinatal exposures to cannabis use disorder (CUD) and the risk of autism spectrum disoder (ASD) in offspring. Data were drawn from the New South Wales (NSW) Perinatal Data Collection (PDC), population-based, linked administrative health data encompassing all-live birth cohort from January 2003 to December 2005. This study involved 222 534 mother-offspring pairs. . The exposure variable (CUD) and the outcome of interest (ASD) were identified using the 10th international disease classification criteria, Australian Modified (ICD-10-AM). We found a three-fold increased risk of ASD in the offspring of mothers with maternal CUD compared to non-exposed offspring. In our sensitivity analyses, male offspring have a higher risk of ASD associated with maternal CUD than their female counterparts. In conclusion, exposure to maternal CUD is linked to a higher risk of ASD in offspring, with a stronger risk in male offspring. Further research is needed to understand these gender-specific effects and the relationship between maternal CUD and ASD risk in children.
Competing Interests: Declaration of competing interest All authors have no conflicts of interest to disclose.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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