Bilateral testicular myxosarcoma in a cryptorchid dog.

Autor: Neves TA; Center for Agricultural Sciences, Federal University of Piauí, Teresina, Piauí, Brazil., Dos Santos WLA; Center for Agricultural Sciences, Federal Rural University of the Semiarid, Mossoró, Rio Grande do Norte, Brazil., Duarte MM; Center for Agricultural Sciences, Federal University of Piauí, Teresina, Piauí, Brazil., Neves CA; Center for Agricultural Sciences, Federal University of Piauí, Teresina, Piauí, Brazil., Batista JS; Center for Agricultural Sciences, Federal Rural University of the Semiarid, Mossoró, Rio Grande do Norte, Brazil., da Silva Teófilo T; Center for Agricultural Sciences, Federal Rural University of the Semiarid, Mossoró, Rio Grande do Norte, Brazil. Electronic address: tiago.teofilo@ufersa.edu.br., Dos Santos Rebouças L; Center for Agricultural Sciences, Federal Rural University of the Semiarid, Mossoró, Rio Grande do Norte, Brazil., Lima AKF; School of Veterinary Medicine and Animal Science, Federal University of Northern Tocantins, Araguína, Tocantins, Brazil., Dias FEF; School of Veterinary Medicine and Animal Science, Federal University of Northern Tocantins, Araguína, Tocantins, Brazil., Arrivabene M; Center for Agricultural Sciences, Federal University of Piauí, Teresina, Piauí, Brazil., Cavalcante TV; Center for Agricultural Sciences, Federal University of Piauí, Teresina, Piauí, Brazil.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2024 Jul; Vol. 174, pp. 105308. Date of Electronic Publication: 2024 May 15.
DOI: 10.1016/j.rvsc.2024.105308
Abstrakt: Myxosarcoma is a rare malignant mesenchymal neoplasm of soft tissues originating from fibroblasts. This report describes a case of bilateral myxosarcoma in a three-year-old cryptorchid dog. The animal was referred to the veterinary clinic because of the absence of testicles in the scrotum. Ultrasonography revealed two masses in the abdominal cavity with testicular echotexture. Exploratory laparotomy revealed the presence of cryptorchid testicles, and orchiectomy was recommended to treat the animal. Testicles were gray and reddish in color and enlarged with firm consistency. For histopathological analysis, testis fragments were fixed in 10% formalin and stained with hematoxylin and eosin and Alcian blue. Immunohistochemistry was performed using the following primary antibodies:1A4, HHF35, desmin, glial fibrillary acidic protein, CD31, S-100, vimentin, and Ki-67. Histopathological evaluation revealed the proliferation of fusiform and round cells associated with extensive areas of myxoid matrix. Neoplasms featured multinucleated giant cells, pleomorphism, karyomegaly, nuclear hyperchromasia, anisokaryosis, mitoses, and necrosis, with coarse chromatin and prominent nucleoli. Immunohistochemical analysis of vimentin- and the Alcian blue-positive cells confirmed the diagnosis of myxosarcoma. A high mitotic count and Ki-67 proliferative index suggests this myxosarcoma had a high degree of malignancy. To the best of our knowledge, this is the first case report of bilateral testicular myxosarcoma in a cryptorchid animal.
Competing Interests: Declaration of competing interest The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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