Acceptability of an Orange-Flavoured Zinc Sulphate Dispersible Tablet in the Management of Acute Diarrhoea in Under-five Children in Lagos, Nigeria.

Autor:	David AN; Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos. E-mail: nkiru_d@yahoo.com; +2348033220631., Olojo I; Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos. E-mail: nkiru_d@yahoo.com; +2348033220631., Salako AO; Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos. E-mail: nkiru_d@yahoo.com; +2348033220631., Odubela O; Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos. E-mail: nkiru_d@yahoo.com; +2348033220631., Ogbe E; R-Jolad Hospital, Gbagada, Lagos., Alake MO; Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos. E-mail: nkiru_d@yahoo.com; +2348033220631., Oba A; Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos. E-mail: nkiru_d@yahoo.com; +2348033220631., Uche-Nwachu F; Emzor Pharmaceutical Industries, Lagos.
Jazyk:	angličtina
Zdroj:	West African journal of medicine [West Afr J Med] 2024 Mar 29; Vol. 41 (3), pp. 258-264.
Abstrakt:	Background: Acute diarrhoea is a significant cause of morbidity and mortality in children under five, especially in subSaharan Africa. The WHO recommends using oral rehydration solution (ORS) and zinc therapy for its management, but the metallic taste of zinc often hinders adherence. Method: This prospective open-label intervention study took place at three health facilities in Lagos, Southwest Nigeria, involving children aged 3 to 59 months with acute diarrhoea. Sociodemographic and diarrhoea-related data were obtained. Palatability was assessed using a 5-point hedonic scale, and adherence was determined by the proportion of prescribed zinc sulfate tablets consumed. Caregivers received a 10-day supply of the study drug and ORS sachets for each child, along with participant diaries for tracking drug intake, palatability scores, and adverse events. Follow-up was conducted on Days 3 and 7, and diaries were collected between Days 10 and 14. Results: Out of the 294 participants, most caregivers were mothers (86.0%), had at least a secondary education (88.1%), and were employed (70.7%). The majority of children were male (54.2%), and under 18 months old (52.2%). The average palatability score was 2.65 (±0.78), with no significant differences based on age or gender. Mean adherence was 93.03%, with 89.3% achieving ≥80% adherence, and adherence did not significantly differ by age or gender. The only reported adverse event, vomiting, decreased from 18.8% on Day 1 to 0.5% on Day 10. Conclusion: The study indicates that the orange-flavored dispersible zinc sulfate tablet is well-accepted by children aged 3 to 59 months with acute diarrhoea in Lagos, Nigeria. Competing Interests: The Authors declare that no competing interest exists (Copyright © 2024 by West African Journal of Medicine.)
Databáze:	MEDLINE
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