Reliability of a Smartphone App to Objectively Monitor Performance Outcomes in Degenerative Cervical Myelopathy: Observational Study.

Autor:	Yanez Touzet A; School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.; MoveMed Ltd., Cambridge, United Kingdom., Houhou T; Division of Science, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates., Rahic Z; Division of Science, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates., Kolias A; Division of Neurosurgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom.; ANAPLASI Rehabilitation Centre, Athens, Greece.; 1st Neurosurgery Department, Henry Dunant Hospital Center, Athens, Greece., Yordanov S; Division of Neurosurgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom., Anderson DB; Faculty of Medicine and Health, Sydney School of Health Sciences, The University of Sydney, Sydney, Australia., Laufer I; New York University Langone Health, New York, NY, United States., Li M; Faculty of Medicine and Health, Sydney School of Health Sciences, The University of Sydney, Sydney, Australia., Grahovac G; King's College Hospital, Kings NHS Foundation Trust, Denmark Hill, London, United Kingdom., Kotter MR; MoveMed Ltd., Cambridge, United Kingdom.; Department of Clinical Neurosurgery, University of Cambridge, Cambridge, United Kingdom.; Department of Clinical Neurosciences, Ann McLaron Laboratory of Regenerative Medicine, Cambridge, United Kingdom., Davies BM; MoveMed Ltd., Cambridge, United Kingdom.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Jazyk:	angličtina
Zdroj:	JMIR formative research [JMIR Form Res] 2024 May 24; Vol. 8, pp. e56889. Date of Electronic Publication: 2024 May 24.
DOI:	10.2196/56889
Abstrakt:	Background: Developing new clinical measures for degenerative cervical myelopathy (DCM) is an AO Spine RECODE-DCM Research, an international and multi-stakeholder partnership, priority. Difficulties in detecting DCM and its changes cause diagnostic and treatment delays in clinical settings and heightened costs in clinical trials due to elevated recruitment targets. Digital outcome measures can tackle these challenges due to their ability to measure disease remotely, repeatedly, and more economically. Objective: The aim of this study is to assess the reliability of the MoveMed battery of performance outcome measures. Methods: A prospective observational study in decentralized secondary care was performed in England, United Kingdom. The primary outcome was to determine the test-retest reliability of the MoveMed performance outcomes using the intraclass correlation (ICC) of agreement . The secondary outcome was to determine the measurement error of the MoveMed performance outcomes using both the SE of the mean (SEM) of agreement and the smallest detectable change (SDC) of agreement . Criteria from the Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) manual were used to determine adequate reliability (ie, ICC of agreement ≥0.7) and risk of bias. Disease stability was controlled using 2 minimum clinically important difference (MCID) thresholds obtained from the literature on the patient-derived modified Japanese Orthopaedic Association (p-mJOA) score, namely, MCID ≤1 point and MCID ≤2 points. Results: In total, 7 adults aged 59.5 (SD 12.4) years who live with DCM and possess an approved smartphone participated in the study. All tests demonstrated moderate to excellent test-retest coefficients and low measurement errors. In the MCID ≤1 group, ICC of agreement values were 0.84-0.94 in the fast tap test, 0.89-0.95 in the hold test, 0.95 in the typing test, and 0.98 in the stand and walk test. SEM of agreement values were ±1 tap, ±1%-3% stability score points, ±0.06 keys per second, and ±10 steps per minute, respectively. SDC of agreement values were ±3 taps, ±4%-7% stability score points, ±0.2 keys per second, and ±27 steps per minute, respectively. In the MCID ≤2 group, ICC of agreement values were 0.61-0.91, 0.75-0.77, 0.98, and 0.62, respectively; SEM of agreement values were ±1 tap, ±2%-4% stability score points, ±0.06 keys per second, and ±10 steps per minute, respectively; and SDC of agreement values were ±3-7 taps, ±7%-10% stability score points, ±0.2 keys per second, and ±27 steps per minute, respectively. Furthermore, the fast tap, hold, and typing tests obtained sufficient ratings (ICC of agreement ≥0.7) in both MCID ≤1 and MCID ≤2 groups. No risk of bias factors from the COSMIN Risk of Bias checklist were recorded. Conclusions: The criteria from COSMIN provide "very good" quality evidence of the reliability of the MoveMed tests in an adult population living with DCM. (©Alvaro Yanez Touzet, Tatiana Houhou, Zerina Rahic, Angelos Kolias, Stefan Yordanov, David B Anderson, Ilya Laufer, Maggie Li, Gordan Grahovac, Mark RN Kotter, Benjamin M Davies, MoveMed Ltd. Originally published in JMIR Formative Research (https://formative.jmir.org), 24.05.2024.)
Databáze:	MEDLINE
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