An Isotonic Drink Containing Pacific Cod ( Gadus macrocephalus ) Processing Waste Collagen Hydrolysate for Bone and Cartilage Health.

Autor: Zarubin NY; Russian Federal Research Institute of Fisheries and Oceanography, 19 Okruzhnoy Proyezd, 105187 Moscow, Russia.; Polar Branch, Russian Federal Research Institute of Fisheries and Oceanography, 6 Akademik Knipovich Str., 183038 Murmansk, Russia., Kharenko EN; Russian Federal Research Institute of Fisheries and Oceanography, 19 Okruzhnoy Proyezd, 105187 Moscow, Russia.; Polar Branch, Russian Federal Research Institute of Fisheries and Oceanography, 6 Akademik Knipovich Str., 183038 Murmansk, Russia., Bredikhina OV; Russian Federal Research Institute of Fisheries and Oceanography, 19 Okruzhnoy Proyezd, 105187 Moscow, Russia.; Polar Branch, Russian Federal Research Institute of Fisheries and Oceanography, 6 Akademik Knipovich Str., 183038 Murmansk, Russia., Lavrukhina EV; Russian Federal Research Institute of Fisheries and Oceanography, 19 Okruzhnoy Proyezd, 105187 Moscow, Russia.; Polar Branch, Russian Federal Research Institute of Fisheries and Oceanography, 6 Akademik Knipovich Str., 183038 Murmansk, Russia., Rysakova KS; Russian Federal Research Institute of Fisheries and Oceanography, 19 Okruzhnoy Proyezd, 105187 Moscow, Russia.; Polar Branch, Russian Federal Research Institute of Fisheries and Oceanography, 6 Akademik Knipovich Str., 183038 Murmansk, Russia., Novikov VY; Russian Federal Research Institute of Fisheries and Oceanography, 19 Okruzhnoy Proyezd, 105187 Moscow, Russia.; Polar Branch, Russian Federal Research Institute of Fisheries and Oceanography, 6 Akademik Knipovich Str., 183038 Murmansk, Russia., Leonov GE; Institute of Biomedical Chemistry, 10 Pogodinskaya Str., 119121 Moscow, Russia., Vakhrushev IV; Institute of Biomedical Chemistry, 10 Pogodinskaya Str., 119121 Moscow, Russia., Zolotarev KV; Institute of Biomedical Chemistry, 10 Pogodinskaya Str., 119121 Moscow, Russia., Mikhailov AN; Institute of Biomedical Chemistry, 10 Pogodinskaya Str., 119121 Moscow, Russia., Mikhailova MV; Institute of Biomedical Chemistry, 10 Pogodinskaya Str., 119121 Moscow, Russia.
Jazyk: angličtina
Zdroj: Marine drugs [Mar Drugs] 2024 Apr 27; Vol. 22 (5). Date of Electronic Publication: 2024 Apr 27.
DOI: 10.3390/md22050202
Abstrakt: Malnutrition is one of the major factors of bone and cartilage disorders. Pacific cod ( Gadus macrocephalus ) processing waste is a cheap and highly promising source of bioactive substances, including collagen-derived peptides and amino acids, for bone and cartilage structure stabilization. The addition of these substances to a functional drink is one of the ways to achieve their fast intestinal absorption. Collagen hydrolysate was obtained via enzymatic hydrolysis, ultrafiltration, freeze-drying, and grinding to powder. The lyophilized hydrolysate was a light gray powder with high protein content (>90%), including collagen (about 85% of total protein) and a complete set of essential and non-essential amino acids. The hydrolysate had no observed adverse effect on human mesenchymal stem cell morphology, viability, or proliferation. The hydrolysate was applicable as a protein food supply or a structure-forming food component due to the presence of collagen fiber fragments. An isotonic fitness drink (osmolality 298.1 ± 2.1 mOsm/L) containing hydrolysate and vitamin C as a cofactor in collagen biosynthesis was prepared. The addition of the hydrolysate did not adversely affect its organoleptic parameters. The production of such functional foods and drinks is one of the beneficial ways of fish processing waste utilization.
Databáze: MEDLINE
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