| Autor: |
Kardaras G; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Christodorescu R; Department V Internal Medicine, Faculty of Medicine, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Boariu M; Department of Endodontics, Faculty of Dental Medicine, TADERP Research Center, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Rusu D; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Belova A; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Chinnici S; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Vela O; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Radulescu V; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Boia S; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Stratul SI; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania. |
| Abstrakt: |
In severe stages of periodontitis, conventional periodontal therapy and maintenance care are usually insufficient due to the viral and bacterial etiology; thus, a mechanical approach alone may not be sufficient to eliminate a substantial portion of subgingival pathogens, especially in deep periodontal sites. Background and Objectives : This single-blind, randomized clinical trial aimed to compare the clinical and microbiological efficacy of a low-cost protocol using povidone-iodine and sodium hypochlorite formulations as adjuncts to non-surgical therapy for patients with stage IV periodontitis when compared with chlorhexidine, the most commonly employed substance to date for antimicrobial regimens in periodontal therapy. Materials and Methods : Forty-five patients were randomly divided into two groups: control (subgingival instrumentation, chlorhexidine-assisted) and test (antiviral medication, subgingival instrumentation with povidone-iodine, sodium hypochlorite rinsing solution, and antibiotics). Clinical measurements and microbiological analyses were performed at baseline and after three months. Results : After three months, notable differences were found in the bacterial detection scores for Porphyromonas gingivalis (a significant reduction in detection frequency was observed in the test compared to the control ( p = 0.021)), and there were significant reductions in detection in the test group for Tannerella forsythia and Treponema denticola , showing undetectable levels ( p < 0.0001 for both). In the test group, the pocket probing depth median value was reduced significantly ( p = 0.0005); similarly, bleeding on probing showed a marked decrease ( p < 0.0001). However, changes in clinical attachment loss and full-mouth plaque score were not statistically significant. Conclusions : Using the proposed protocol, substantial improvements in clinical and microbiological parameters were obtained when compared with the current antimicrobial recommendations. |
