Açaí ( Euterpe oleracea Mart. ) Seed Oil and Its Nanoemulsion: Chemical Characterisation, Toxicity Evaluation, Antioxidant and Anticancer Activities.

Autor: Borges KRA; Northeast Biotechnology Postgraduate Program, Renorbio, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Saõ Luis 65080-085, Maranhao, Brazil., Wolff LAS; Adult Health Master's Postgraduate Program-PPGSAD, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Saõ Luis 65080-085, Maranhao, Brazil., da Silva MACN; Medicine Course, Federal University of Maranhao, Imperatriz 65915-060, Maranhao, Brazil., de Carvalho Silva AK; Northeast Biotechnology Postgraduate Program, Renorbio, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Saõ Luis 65080-085, Maranhao, Brazil., Campos CDL; Postgraduate Program in Health Sciences, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Saõ Luis 65080-085, Maranhao, Brazil., Souza FS; Postgraduate Program in Biodiversity and Biotechnology of the Bionorte Network, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Saõ Luis 65080-085, Maranhao, Brazil., Teles AM; Professional Postgradualte Program in Animal Health Defense, State University of Maranhão, Av. Oeste Externa, 2220-São Cristóvão, São Luís 65010-120, Maranhao, Brazil., Vale AÁM; Postgraduate Program in Health Sciences, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Saõ Luis 65080-085, Maranhao, Brazil., Pascoa H; Farmatec Laboratory at the Federal University of Goiás, Campus Samambaia da UFG, Goiânia 74690-631, Goiás, Brazil., Lima EM; Farmatec Laboratory at the Federal University of Goiás, Campus Samambaia da UFG, Goiânia 74690-631, Goiás, Brazil., de Sousa EM; Graduate Program in Biosciences Applied to Health, CEUMA Universitity, São Luís 65075-120, Maranhão, Brazil., Nunes ACS; Coordination of the Chemical Engineering course, Center for Exact Sciences and Technology, Federal University of Maranhao (UFMA), São Luís 65080-085, Maranhão, Brazil., Gil da Costa RM; Postgraduate Program in Health Sciences, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Saõ Luis 65080-085, Maranhao, Brazil.; Centre for the Research and Technology of Agro-Environmental and Biological Sciences, Universidade de Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal.; Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto), Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal.; Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE), Faculty of Engineering, University of Porto (FEUP), 4200-465 Porto, Portugal.; Associate Laboratory in Chemical Engineering (ALiCE), University of Porto (FEUP), 4200-465 Porto, Portugal., Faustino-Rocha AI; Centre for the Research and Technology of Agro-Environmental and Biological Sciences, Universidade de Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal.; Comprehensive Health Research Center (CHRC), 7006-554 Évora, Portugal.; Department of Zootechnics, School of Sciences and Technology, University of Évora, 7002-554 Évora, Portugal., Cardoso Carvalho R; Postgraduate Program in Health Sciences, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Saõ Luis 65080-085, Maranhao, Brazil., Nascimento MDDSB; Northeast Biotechnology Postgraduate Program, Renorbio, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Saõ Luis 65080-085, Maranhao, Brazil.; Adult Health Master's Postgraduate Program-PPGSAD, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Saõ Luis 65080-085, Maranhao, Brazil.
Jazyk: angličtina
Zdroj: Current issues in molecular biology [Curr Issues Mol Biol] 2024 Apr 23; Vol. 46 (5), pp. 3763-3793. Date of Electronic Publication: 2024 Apr 23.
DOI: 10.3390/cimb46050235
Abstrakt: This study explores a nanoemulsion formulated with açaí seed oil, known for its rich fatty acid composition and diverse biological activities. This study aimed to characterise a nanoemulsion formulated with açaí seed oil and explore its cytotoxic effects on HeLa and SiHa cervical cancer cell lines, alongside assessing its antioxidant and toxicity properties both in vitro and in vivo. Extracted from fruits sourced in Brazil, the oil underwent thorough chemical characterization using gas chromatography-mass spectrometry. The resulting nanoemulsion was prepared and evaluated for stability, particle size, and antioxidant properties. The nanoemulsion exhibited translucency, fluidity, and stability post centrifugation and temperature tests, with a droplet size of 238.37, PDI -9.59, pH 7, and turbidity 0.267. In vitro assessments on cervical cancer cell lines revealed antitumour effects, including inhibition of cell proliferation, migration, and colony formation. Toxicity tests conducted in cell cultures and female Swiss mice demonstrated no adverse effects of both açaí seed oil and nanoemulsion. Overall, açaí seed oil, particularly when formulated into a nanoemulsion, presents potential for cancer treatment due to its bioactive properties and safety profile.
Databáze: MEDLINE