The Significance of Thyroid Hormone Receptors in Breast Cancer: A Hypothesis-Generating Narrative Review.

Autor: Quan T; Division of Medical Oncology, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON M4N 3M5, Canada., Cockburn J; University Health Network, Toronto, ON M5G 2C4, Canada., Dhesy-Thind S; Department of Oncology, Juravinski Cancer Centre, 699 Concession St, Hamilton, ON L8V 5C2, Canada., Bane A; University Health Network, Toronto, ON M5G 2C4, Canada., Leong H; Department of Medical Biophysics Temerty, Faculty of Medicine, University of Toronto, Toronto, ON M4N 3M5, Canada.; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada., Geleff C; Department of Medical Biophysics Temerty, Faculty of Medicine, University of Toronto, Toronto, ON M4N 3M5, Canada., Devion C; Library Services, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada., Ajel N; Division of Medical Oncology, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON M4N 3M5, Canada., Jerzak KJ; Division of Medical Oncology, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON M4N 3M5, Canada.; Library Services, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
Jazyk: angličtina
Zdroj: Current oncology (Toronto, Ont.) [Curr Oncol] 2024 Apr 23; Vol. 31 (5), pp. 2364-2375. Date of Electronic Publication: 2024 Apr 23.
DOI: 10.3390/curroncol31050176
Abstrakt: Background: Breast cancer (BC) is frequently diagnosed among Canadian women. While targeted therapies are available for most BC patients; treatment resistance is common and novel therapeutic targets are of interest. Thyroid hormones (TH) bound to thyroid hormone receptors (THR) influence cell proliferation and differentiation; they are also involved in the growth and development of normal breast tissue. Evidence suggests that THRβ is a tumor suppressor in various solid tumors.
Purpose: This narrative review discusses retrospective studies regarding the clinical relevance of THRβ as a potential prognostic biomarker and therapeutic target in BC.
Methods: We consulted with an information specialist to develop a search strategy to find all literature related to THRα expression as a potential prognostic and therapeutic biomarker in breast cancer. The primary search was developed for Medline and translated to Embase. The searches were conducted on the Ovid platform on 18 August 2023.
Results: Across seven retrospective studies identified, several have shown an association between higher THRβ1 expression with a lower risk of BC recurrence and with longer overall survival.
Conclusions: Some evidence suggests that THRβ expression is associated with a lower risk of BC recurrence and death. Validation of THRβ as an independent prognostic biomarker and possible predictive biomarker of response to endocrine therapy and/or chemotherapy is of interest. Given that THRβ is upstream of the AKT/PI3K pathway, its potential as a predictive biomarker of response to AKT inhibitors and/or PI3K inhibitors may also be of value. Finally, the potential re-purposing of THRβ agonists as anti-cancer agents warrants investigation.
Databáze: MEDLINE
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