Prevalence and prognosis of malignancy in THSD7A-associated membranous nephropathy: a systematic literature review and clinical case study.

Autor: Xu Q; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China., Li J; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.; Department of Nephrology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China., Yang Y; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China., Zhuo L; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China., Gao H; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China., Jiang S; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China., Li W; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.; Department of Nephrology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
Jazyk: angličtina
Zdroj: Renal failure [Ren Fail] 2024 Dec; Vol. 46 (1), pp. 2355353. Date of Electronic Publication: 2024 May 24.
DOI: 10.1080/0886022X.2024.2355353
Abstrakt: Background: This study aims to investigate the incidence and prognosis of malignancy in individuals with thrombospondin type-1 domain-containing 7A (THSD7A)-associated membranous nephropathy (MN).
Methods: First, we performed a systematic literature review of prevalence of malignancy in THSD7A-associated MN. Then, we conducted a retrospective analysis of 454 patients diagnosed with MN through renal biopsy at our hospital between January 2016 and December 2020. We assessed the presence of serum anti-THSD7A antibodies and performed immunohistochemical staining of renal tissue for THSD7A. Subsequently, we followed patients with THSD7A-associated MN for a minimum of 3-5 years, collecting their clinical, pathological characteristics, and prognosis. Additionally, we conducted a literature review on patients with THSD7A-associated MN in conjunction with malignancy.
Results: We identified a total of nine articles containing comprehensive data on THSD7A-associated MN and malignancy. Among 235 patients with THSD7A-positive MN, 36 individuals had concurrent malignancies, resulting in a malignancy prevalence of 13.3% (95% CI: 8.9-17.7%). In our center, we followed up with 15 patients diagnosed with THSD7A-associated MN and observed three cases of concomitant tumors: two cases of lung adenocarcinoma and one case of small cell lung cancer with multiple metastases. The prevalence of malignancy in our cohort was 20%. Notably, we detected positive THSD7A staining in both renal and lung cancer tissues in one patient with small cell lung cancer.
Conclusions: Patients with THSD7A-associated MN should undergo vigilant follow-up assessments, with a particular focus on actively seeking potential tumorigenic lesions to prevent misdiagnosis or oversight.
Databáze: MEDLINE
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