Impact of oral administration of calcitriol to prevent symptomatic hypocalcemia after total thyroidectomy: Systematic review and meta-analysis.

Autor:	Dadkhah PA; Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Farshid A; Student Research Committee, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran., Khademi R; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Yaghoubi S; Student Research Committee, Faculty of Medicine, Islamic Azad University of Ardabil, Ardabil, Iran., Asadzadeh A; Student Research Committee, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran., Moharamnejad N; Student Research Committee, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran., Jadidian F; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ziaei SA; Student Research Committee, Fasa University of Medical Sciences, Fars, Iran., Haghshoar S; Faculty of Pharmacy, Cyprus International University, Nicosia, Cyprus., Salimi O; Student Research Committee, Faculty of Medicine, Islamic Azad University of Najafabad, Isfahan, Iran., Shafagh SG; Faculty of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran., Rabiei N; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran., Shahsavari S; Department of Surgery, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Shokravi S; Department of Research and Academic Affairs, Larkin Community Hospital, Miami, FL, USA., Maroufi Z; Student Research Committee, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Deravi N; Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Erabi G; Student Research Committee Urmia University of Medical Sciences Resaalat Ave. 5714783734 Urmia Iran., Naziri M; Student Research Committee School of Medicine Iran University of Medical Sciences (IUMS) Shahid Hemmat Highway 14496-14535 Tehran Iran.
Jazyk:	angličtina
Zdroj:	Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society [Scand J Surg] 2024 May 24, pp. 14574969241251899. Date of Electronic Publication: 2024 May 24.
DOI:	10.1177/14574969241251899
Abstrakt:	Background: One of the most common complications of total thyroidectomy is post-operative transient or persistent hypoparathyroidism that can cause symptomatic hypocalcaemia. To prevent this complication, shorten the period of hospitalization and reduce morbidity, routine supplementation of oral vitamin D and calcium has been suggested. This systematic review and meta-analysis aims to critically assess the association between pre-operative calcitriol supplementation and post-operative hypocalcaemia. Methods: Randomized controlled trial studies were identified by searching PubMed, Scopus, and Google Scholar databases up to 30 March 2023. Screening of titles, abstracts, and full texts of articles were performed, and data were extracted for a meta-analysis. Results: This meta-analysis includes data from nine randomized controlled trials with a total of 1259 patients but with significant heterogeneity. The results demonstrate that calcium levels were higher in patients who had pre-operative calcitriol supplementation, with a weighted mean difference (WMD) 0.18 (95% confidence interval (CI) = 0.00, 0.37). Pre-operative calcitriol supplementation did not lead to significant changes in parathyroid hormone (PTH) levels, with WMD -0.49 (95% CI: -1.91, 0.94). Conclusion: Pre-operative calcitriol supplementation leads to higher calcium levels, but the high heterogeneity of the included studies (79% to 98.7%) could affect the results. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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