The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials.

Autor:	Fieldhouse JLP; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands., van Paassen DN; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands., van Engelen ME; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands., De Boer SCM; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands., Hartog WL; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands., Braak S; Department of Psychiatry, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Netherlands., Schoonmade LJ; Medical Library, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Schouws SNTM; Department of Psychiatry, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; GGZ inGeest Mental Health Care, Amsterdam, Netherlands., Krudop WA; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; GGZ inGeest Mental Health Care, Amsterdam, Netherlands., Oudega ML; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands.; Department of Psychiatry, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Netherlands.; GGZ inGeest Mental Health Care, Amsterdam, Netherlands., Mutsaerts HJMM; Department of Radiology and Nuclear Medicine, Amsterdam UMC Location VUmc, Amsterdam, Netherlands., Teunissen CE; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands.; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC Location VUmc, Amsterdam, Netherlands., Vijverberg EGB; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands., Pijnenburg YAL; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2024 May 09; Vol. 16, pp. 1382593. Date of Electronic Publication: 2024 May 09 (Print Publication: 2024).
DOI:	10.3389/fnagi.2024.1382593
Abstrakt:	Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder characterized by diverse and prominent changes in behavior and personality. One of the greatest challenges in bvFTD is to capture, measure and predict its disease progression, due to clinical, pathological and genetic heterogeneity. Availability of reliable outcome measures is pivotal for future clinical trials and disease monitoring. Detection of change should be objective, clinically meaningful and easily assessed, preferably associated with a biological process. The purpose of this scoping review is to examine the status of longitudinal studies in bvFTD, evaluate current assessment tools and propose potential progression markers. A systematic literature search (in PubMed and Embase.com) was performed. Literature on disease trajectories and longitudinal validity of frequently-used measures was organized in five domains: global functioning, behavior, (social) cognition, neuroimaging and fluid biomarkers. Evaluating current longitudinal data, we propose an adaptive battery, combining a set of sensitive clinical, neuroimaging and fluid markers, adjusted for genetic and sporadic variants, for adequate detection of disease progression in bvFTD. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Fieldhouse, van Paassen, van Engelen, De Boer, Hartog, Braak, Schoonmade, Schouws, Krudop, Oudega, Mutsaerts, Teunissen, Vijverberg and Pijnenburg.)
Databáze:	MEDLINE
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