Pregnancy in women with nephrotic-range proteinuria: A retrospective cohort study.

Autor:	Svetitsky S; Imperial College Healthcare NHS Trust Renal and Transplant Centre, Barts Health NHS Trust, London, United Kingdom of Great Britain and Northern Ireland., Lightstone L; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, United Kingdom of Great Britain and Northern Ireland., Wiles K; Deaprtment of Maternal Medicine, Barts Health NHS Trust, London, United Kingdom of Great Britain and Northern Ireland.
Jazyk:	angličtina
Zdroj:	Obstetric medicine [Obstet Med] 2024 Jun; Vol. 17 (2), pp. 96-100. Date of Electronic Publication: 2023 Oct 09.
DOI:	10.1177/1753495X231201896
Abstrakt:	Background: Obstetric and kidney outcomes following detection of nephrotic-range proteinuria in early pregnancy have not been well described. Methods: A retrospective cohort study of chronic kidney disease (CKD) in pregnancy between 2008 and 2018. Outcomes in those with nephrotic-range proteinuria before 20 weeks' gestation were compared to those without nephrotic-range proteinuria. Results: The study included 37 women with nephrotic-range proteinuria and 62 women without. Pre-pregnancy estimated glomerular filtration rate (eGFR) was similar. Nephrotic-range proteinuria was associated with higher rates of preterm (odds ratio [OR] 1.77, 95% confidence interval [CI]: 1.07-2.92) and early preterm delivery (OR 2.63, 95% CI: 1.12-6.2), and with a requirement for renal replacement therapy at 3 years post-partum (OR 10.72, 95% CI: 2.58-44.47). Tubulointerstitial scarring on kidney biopsy was associated with early preterm delivery and progression to advanced CKD, independent of pre-pregnancy eGFR. Conclusion: Compared to CKD without nephrotic-range proteinuria, nephrotic-range proteinuria early in pregnancy is associated with higher rates of pre-term delivery and progression to advanced CKD. Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article. (© The Author(s) 2023.)
Databáze:	MEDLINE
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